IĸBζ 是炎症性关节炎发病机制的核心调节因子

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2024-09-15 DOI:10.1002/art.42990

Gaurav Swarnkar, Musarrat Naaz, Dorothy Mims, Prashant Gupta, Timothy Peterson, Matthew J. Christopher, Srikanth Singamaneni, Gabriel Mbalaviele, Yousef Abu-Amer

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引用次数: 0

摘要

目前针对炎症性关节炎（IA）中单个因子的疗法疗效不一，通常需要联合用药治疗，并伴有不良副作用。NF-ĸB 对大多数炎症细胞因子的产生和功能至关重要。然而，鉴于 NF-ĸB 在生理过程中的重要作用，靶向 NF-ĸB 并不可靠。因此，确定 NF-κB 下游选择性地控制内脏炎症细胞因子表达的途径将是有利的。我们以前曾发现 IĸBζ 是 NF-ĸB 的一个独特的炎症特征，它只在病理条件下控制炎症细胞因子的转录，而放过生理性 NF-ĸB 信号。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

IĸBζ is a central modulator of inflammatory arthritis pathogenesis

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IĸBζ is a central modulator of inflammatory arthritis pathogenesis

Current therapies targeting individual factors in inflammatory arthritis (IA) show variable efficacy, often requiring treatment using combinations of drugs and associated with undesirable side effects. NF-ĸB is critical for production and function of most inflammatory cytokines. However, given its essential role in physiologic processes, targeting NF-ĸB is precarious. Hence, identifying pathways downstream of NF-κB that selectively govern expression of inflammatory cytokines in IA would be advantageous. We have previously identified IĸBζ as a unique inflammatory signature of NF-ĸB that controls transcription of inflammatory cytokines only under pathologic conditions while sparing physiologic NF-ĸB signals.

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.