感知 DNA 的危险：cGAS 的发现

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2024-09-19 DOI:10.1016/j.immuni.2024.09.009

Richard A. Flavell, Esen Sefik

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引用次数: 0

摘要

过去几十年来，对免疫系统如何识别病原体并对其做出反应的深入研究，为生物学和医学带来了里程碑式的进步。今年的 "阿尔伯特-拉斯克基础医学研究奖 "授予陈志坚 "詹姆斯 "发现 cGAS 的荣誉，cGAS 是一种能感知位于细胞内异常位置的外来和 "致病 "自我 DNA 的酶。cGAS-STING 通路的定义为了解和治疗人类疾病开辟了新的前景。

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Sensing DNA as danger: The discovery of cGAS

Insight into how the immune system recognizes and responds to pathogens had led to landmark advances in biology and medicine in the last decades. This year’s Albert Lasker Award for Basic Medical Research honors Zhijian “James” Chen for the discovery of cGAS, the enzyme that senses foreign and “pathogenic” self-DNA—self-DNA aberrantly located in intracellular compartments. The definition of the cGAS-STING pathway opens new horizons for the understanding and treatment of human disease.

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.