完成未完成的工作Chd1 与 FACT 一起解析六聚体-核小体复合物

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2024-09-19 DOI:10.1016/j.molcel.2024.08.031

Hongxin Yin, Yang Liu

引用次数: 0

摘要

在本期的《分子细胞》（Molecular Cell）杂志上，Engeholm 等人1 展示了染色质重塑者 Chd1 与六聚体-核小体复合物结合的冷冻电镜结构，六聚体-核小体复合物是转录过程中的中间状态，可与 FACT 结合或不与 FACT 结合，以恢复缺失的 H2A-H2B 二聚体。这两种结合模式揭示了 Chd1 和 FACT 如何在转录过程中合作重建核小体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Finish the unfinished: Chd1 resolving hexasome-nucleosome complex with FACT

In this issue of Molecular Cell, Engeholm et al.¹ present cryo-EM structures of the chromatin remodeler Chd1 bound to a hexasome-nucleosome complex, an intermediate state during transcription either with or without FACT to restore the missing H2A-H2B dimer. These two binding modes reveal how Chd1 and FACT cooperate in nucleosome re-establishment during transcription.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.