通过倒置部分似然比检验为等效剂量-反应曲线建立有效且小样本量的可信区间

IF 1.8 4区数学 Q1 STATISTICS & PROBABILITY

American Statistician Pub Date : 2024-09-19 DOI:10.1080/00031305.2024.2407478

J. G. Liao

引用次数: 0

摘要

剂量反应曲线对于确定药物的安全剂量至关重要，被广泛应用于生物测定和第一阶段临床试验。一般认为，死亡或...

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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An effective and small sample-size valid confidence interval for isotonic dose-response curves by inverting a partial likelihood ratio test

A dose-response curve is essential for determining the safe dosage of a drug and is widely used in bioassay and in phase 1 clinical trials. It is generally accepted that the probability of death or...

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来源期刊

American Statistician 数学-统计学与概率论

CiteScore

3.50

自引率

5.60%

发文量

审稿时长

>12 weeks

期刊介绍： Are you looking for general-interest articles about current national and international statistical problems and programs; interesting and fun articles of a general nature about statistics and its applications; or the teaching of statistics? Then you are looking for The American Statistician (TAS), published quarterly by the American Statistical Association. TAS contains timely articles organized into the following sections: Statistical Practice, General, Teacher''s Corner, History Corner, Interdisciplinary, Statistical Computing and Graphics, Reviews of Books and Teaching Materials, and Letters to the Editor.