Ramya Ayyalasomayajula, Ivet Boneva, David Ormaza, Andrew Whyte Jr., Kamran Farook, Zachary Gorlin, Evelyn Yancey, Sabine André, Herbert Kaltner, Maré Cudic
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Cover Feature: Synthesis and Thermodynamic Evaluation of Sialyl-Tn MUC1 Glycopeptides Binding to Macrophage Galactose-Type Lectin (ChemBioChem 18/2024)
Isothermal titration calorimetry (ITC) analysis of the binding of hMGL to Tn and sialyl-Tn MUC1 glycopeptides revealed a dynamic process in which lectin molecules bind to carbohydrate ligands and jump from ligand to ligand along the glycopeptides’ backbone. More details can be found in article 10.1002/cbic.202400391 by Maré Cudic and co-workers.
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