为工业应用生产海洋生物活性肽分子：逆向工程方法

IF 12.1 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnology advances Pub Date : 2024-09-10 DOI:10.1016/j.biotechadv.2024.108449

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引用次数: 0

摘要

这篇综述探讨了多种海洋微生物衍生的生物活性肽分子，强调了逆向工程在其生产中的重要意义。文章讨论了海洋天然产物（MNPs）生物制造方面的进展，这些进展是通过整合omics驱动的微生物工程学和生物信息学实现的。文章阐明并介绍了非核糖体合成肽（NRPs）和核糖体合成前体肽（RiPP）生物合成的显著特点。此外，文章还深入探讨了常见肽修饰的起源。文章重点介绍了各种基因组挖掘方法，以有针对性地鉴定生物合成基因簇（BGCs）以及新型 RiPP 和 NRPs 衍生肽。综述旨在展示 RiPP 和 NRP 生物合成途径工程学的进展、前景和障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Production of marine-derived bioactive peptide molecules for industrial applications: A reverse engineering approach

This review examines a wide range of marine microbial-derived bioactive peptide molecules, emphasizing the significance of reverse engineering in their production. The discussion encompasses the advancements in Marine Natural Products (MNPs) bio-manufacturing through the integration of omics-driven microbial engineering and bioinformatics. The distinctive features of non-ribosomally synthesised peptides (NRPs), and ribosomally synthesised precursor peptides (RiPP) biosynthesis is elucidated and presented. Additionally, the article delves into the origins of common peptide modifications. It highlights various genome mining approaches for the targeted identification of Biosynthetic Gene Clusters (BGCs) and novel RiPP and NRPs-derived peptides. The review aims to demonstrate the advancements, prospects, and obstacles in engineering both RiPP and NRP biosynthetic pathways.

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来源期刊

Biotechnology advances 工程技术-生物工程与应用微生物

CiteScore

25.50

自引率

2.50%

发文量

167

审稿时长

37 days

期刊介绍： Biotechnology Advances is a comprehensive review journal that covers all aspects of the multidisciplinary field of biotechnology. The journal focuses on biotechnology principles and their applications in various industries, agriculture, medicine, environmental concerns, and regulatory issues. It publishes authoritative articles that highlight current developments and future trends in the field of biotechnology. The journal invites submissions of manuscripts that are relevant and appropriate. It targets a wide audience, including scientists, engineers, students, instructors, researchers, practitioners, managers, governments, and other stakeholders in the field. Additionally, special issues are published based on selected presentations from recent relevant conferences in collaboration with the organizations hosting those conferences.