Yibo Lu , Jie Shen , Baojie Li , Panpan Zhao , Baokun Li , Zhifeng Fang , Jiancheng Wang , Guoqi Ni , Zhexin Fan
{"title":"地黄 LBK 对小鼠急性镉中毒的保护作用","authors":"Yibo Lu , Jie Shen , Baojie Li , Panpan Zhao , Baokun Li , Zhifeng Fang , Jiancheng Wang , Guoqi Ni , Zhexin Fan","doi":"10.1016/j.fbio.2024.105111","DOIUrl":null,"url":null,"abstract":"<div><p>Cadmium (Cd) is an environmental non-biodegradable pollutant that induces toxic effects in humans. Therefore, there is a pressing need to identify new methods to relieve cadmium-induced toxic damage. In this study, <em>Weizmannia coagulans</em> (formerly termed <em>Bacillus coagulans</em>) LBK, which was isolated from silage feed, exhibited robust Cd tolerance and adsorption capabilities. In vitro experiments demonstrated that its scavenging rate for 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) and hydroxyl radicals was 40% and 39%, respectively. In vivo, LBK significantly reduced the mortality rate of cadmium-exposed mice. Moreover, LBK increased the hepatic levels of superoxide dismutase (SOD) and catalase (CAT), and histopathology examination suggested that LBK could attenuate liver damage. <em>W</em>. <em>coagulans</em> LBK significantly altered the composition of the intestinal microbiota and increased the abundance of beneficial bacteria such as <em>Leptospirillaceae</em> and <em>Lactobacillus</em>. Metabolomics analysis of cecal contents revealed that LBK regulated amino acid metabolic disorders caused by Cd exposure and restored the levels of glutamic acid, leucine, and aspartic acid. Based on the aforementioned advantages, <em>W. coagulans</em> LBK may be considered a promising candidate for alleviating oxidative stress caused by acute Cd exposure.</p></div>","PeriodicalId":12409,"journal":{"name":"Food Bioscience","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Protective effects of Weizmannia coagulans LBK against acute cadmium toxicity in mice\",\"authors\":\"Yibo Lu , Jie Shen , Baojie Li , Panpan Zhao , Baokun Li , Zhifeng Fang , Jiancheng Wang , Guoqi Ni , Zhexin Fan\",\"doi\":\"10.1016/j.fbio.2024.105111\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Cadmium (Cd) is an environmental non-biodegradable pollutant that induces toxic effects in humans. Therefore, there is a pressing need to identify new methods to relieve cadmium-induced toxic damage. In this study, <em>Weizmannia coagulans</em> (formerly termed <em>Bacillus coagulans</em>) LBK, which was isolated from silage feed, exhibited robust Cd tolerance and adsorption capabilities. In vitro experiments demonstrated that its scavenging rate for 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) and hydroxyl radicals was 40% and 39%, respectively. In vivo, LBK significantly reduced the mortality rate of cadmium-exposed mice. Moreover, LBK increased the hepatic levels of superoxide dismutase (SOD) and catalase (CAT), and histopathology examination suggested that LBK could attenuate liver damage. <em>W</em>. <em>coagulans</em> LBK significantly altered the composition of the intestinal microbiota and increased the abundance of beneficial bacteria such as <em>Leptospirillaceae</em> and <em>Lactobacillus</em>. Metabolomics analysis of cecal contents revealed that LBK regulated amino acid metabolic disorders caused by Cd exposure and restored the levels of glutamic acid, leucine, and aspartic acid. Based on the aforementioned advantages, <em>W. coagulans</em> LBK may be considered a promising candidate for alleviating oxidative stress caused by acute Cd exposure.</p></div>\",\"PeriodicalId\":12409,\"journal\":{\"name\":\"Food Bioscience\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Food Bioscience\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2212429224015414\",\"RegionNum\":1,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Food Bioscience","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2212429224015414","RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Protective effects of Weizmannia coagulans LBK against acute cadmium toxicity in mice
Cadmium (Cd) is an environmental non-biodegradable pollutant that induces toxic effects in humans. Therefore, there is a pressing need to identify new methods to relieve cadmium-induced toxic damage. In this study, Weizmannia coagulans (formerly termed Bacillus coagulans) LBK, which was isolated from silage feed, exhibited robust Cd tolerance and adsorption capabilities. In vitro experiments demonstrated that its scavenging rate for 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) and hydroxyl radicals was 40% and 39%, respectively. In vivo, LBK significantly reduced the mortality rate of cadmium-exposed mice. Moreover, LBK increased the hepatic levels of superoxide dismutase (SOD) and catalase (CAT), and histopathology examination suggested that LBK could attenuate liver damage. W. coagulans LBK significantly altered the composition of the intestinal microbiota and increased the abundance of beneficial bacteria such as Leptospirillaceae and Lactobacillus. Metabolomics analysis of cecal contents revealed that LBK regulated amino acid metabolic disorders caused by Cd exposure and restored the levels of glutamic acid, leucine, and aspartic acid. Based on the aforementioned advantages, W. coagulans LBK may be considered a promising candidate for alleviating oxidative stress caused by acute Cd exposure.
Food BioscienceBiochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
6.40
自引率
5.80%
发文量
671
审稿时长
27 days
期刊介绍:
Food Bioscience is a peer-reviewed journal that aims to provide a forum for recent developments in the field of bio-related food research. The journal focuses on both fundamental and applied research worldwide, with special attention to ethnic and cultural aspects of food bioresearch.