化学限制 PU.1 基因组结合位点可激活交替基因网络

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2024-09-18 DOI:10.1038/s41588-024-01912-6

引用次数: 0

摘要

用小分子阻断主要基因组结合位点会导致转录因子 PU.1 重新分布到替代结合位点；它在这些位点的转录活性会激活次级基因网络，从而驱动髓系细胞分化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Chemical restriction of PU.1 genomic binding sites activates alternate gene networks

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Chemical restriction of PU.1 genomic binding sites activates alternate gene networks

Blockade of primary genomic binding sites with small molecules causes redistribution of the transcription factor PU.1 to alternative binding sites; its transcriptional activity at these sites activates secondary gene networks that drive myeloid cell differentiation.

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution