抑制转录活跃的艾滋病毒库，改善治疗效果

IF 20.5 1区生物学 Q1 MICROBIOLOGY

Nature Microbiology Pub Date : 2024-09-17 DOI:10.1038/s41564-024-01816-5

Julia Prigann, Rubens Tavora, Robert L. Furler O’Brien, Ursula Schulze-Gahmen, Daniela Boehm, Nadia R. Roan, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana Valente, Melanie Ott

{"title":"抑制转录活跃的艾滋病毒库，改善治疗效果","authors":"Julia Prigann, Rubens Tavora, Robert L. Furler O’Brien, Ursula Schulze-Gahmen, Daniela Boehm, Nadia R. Roan, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana Valente, Melanie Ott","doi":"10.1038/s41564-024-01816-5","DOIUrl":null,"url":null,"abstract":"Persistence of the transcriptionally active HIV reservoir has important implications for people living with HIV, including chronic immune activation and inflammation. Supplementing antiretroviral therapy with transcriptional inhibitors could overcome this by silencing the transcriptionally active HIV reservoir.","PeriodicalId":18992,"journal":{"name":"Nature Microbiology","volume":null,"pages":null},"PeriodicalIF":20.5000,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Silencing the transcriptionally active HIV reservoir to improve treatment outcomes\",\"authors\":\"Julia Prigann, Rubens Tavora, Robert L. Furler O’Brien, Ursula Schulze-Gahmen, Daniela Boehm, Nadia R. Roan, Douglas F. Nixon, Lishomwa C. Ndhlovu, Susana Valente, Melanie Ott\",\"doi\":\"10.1038/s41564-024-01816-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Persistence of the transcriptionally active HIV reservoir has important implications for people living with HIV, including chronic immune activation and inflammation. Supplementing antiretroviral therapy with transcriptional inhibitors could overcome this by silencing the transcriptionally active HIV reservoir.\",\"PeriodicalId\":18992,\"journal\":{\"name\":\"Nature Microbiology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":20.5000,\"publicationDate\":\"2024-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Microbiology\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1038/s41564-024-01816-5\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1038/s41564-024-01816-5","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

转录活跃的艾滋病毒库的持续存在对艾滋病毒感染者有重要影响，包括慢性免疫激活和炎症。用转录抑制剂辅助抗逆转录病毒疗法，可以抑制转录活跃的艾滋病病毒库，从而克服这一问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Silencing the transcriptionally active HIV reservoir to improve treatment outcomes

查看原文本刊更多论文

Silencing the transcriptionally active HIV reservoir to improve treatment outcomes

Persistence of the transcriptionally active HIV reservoir has important implications for people living with HIV, including chronic immune activation and inflammation. Supplementing antiretroviral therapy with transcriptional inhibitors could overcome this by silencing the transcriptionally active HIV reservoir.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Microbiology Immunology and Microbiology-Microbiology

CiteScore

44.40

自引率

1.10%

发文量

226

期刊介绍： Nature Microbiology aims to cover a comprehensive range of topics related to microorganisms. This includes: Evolution: The journal is interested in exploring the evolutionary aspects of microorganisms. This may include research on their genetic diversity, adaptation, and speciation over time. Physiology and cell biology: Nature Microbiology seeks to understand the functions and characteristics of microorganisms at the cellular and physiological levels. This may involve studying their metabolism, growth patterns, and cellular processes. Interactions: The journal focuses on the interactions microorganisms have with each other, as well as their interactions with hosts or the environment. This encompasses investigations into microbial communities, symbiotic relationships, and microbial responses to different environments. Societal significance: Nature Microbiology recognizes the societal impact of microorganisms and welcomes studies that explore their practical applications. This may include research on microbial diseases, biotechnology, or environmental remediation. In summary, Nature Microbiology is interested in research related to the evolution, physiology and cell biology of microorganisms, their interactions, and their societal relevance.