贝尔氏麻痹的运动单位数量指数:用于早期评估的潜在电生理生物标志物

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Mengjie Chen, Mingxia Zhu, Xiuli Li, Jingtao Pi, Xinhong Feng
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引用次数: 0

摘要

导言:贝尔氏麻痹会导致面瘫和生活质量下降,而可靠、无创的贝尔氏麻痹神经肌肉功能早期诊断方法仍有待建立。在此,我们旨在评估运动单位数量指数(MUNIX)对早期贝尔氏麻痹的定量电生理评估的实用性、其与临床评估的相关性、治疗后的变化以及与临床预后的关联。 方法 从 10 名健康人和 64 名贝尔氏麻痹患者的双侧颧肌、眼轮匝肌和口轮匝肌记录 MUNIX 测量值。两名神经科专家使用 House-Brackmann 和 Sunnybrook 面部分级系统对患者进行了评估。对接受治疗的 20 名贝尔麻痹患者进行了重复评估。此外,在间隔 1 个月后,还使用临床量表对 64 名患者进行了重新评估。 结果 贝尔氏麻痹患者患侧主要受影响肌肉的 MUNIX 值低于健侧(p <.05)。MUNIX 测量值与临床面神经麻痹量表评分明显相关(p < .05)。在治疗后的重复测试中,观察到 MUNIX 值有明显改善(p <.05)。基线运动单位大小指数(复合肌肉动作电位振幅除以 MUNIX)与 1 个月后临床表现的改善呈正相关(p < .05)。 结论 MUNIX 可作为电生理生物标志物,用于定量评估面神经麻痹和治疗反应,也可作为早期贝尔氏麻痹患者的预后生物标志物,建议作为传统神经电生理检查的补充。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Motor unit number index in Bell's palsy: A potential electrophysiological biomarker for early evaluation

Motor unit number index in Bell's palsy: A potential electrophysiological biomarker for early evaluation

Introduction

Reliable, noninvasive early diagnostics of neuromuscular function in Bell's palsy, which causes facial paralysis and reduced quality of life, remain to be established. Here, we aimed to evaluate the utility of the motor unit number index (MUNIX) for the quantitative electrophysiological assessment of early-stage Bell's palsy, its correlation with clinical assessments, changes following treatment, and association with clinical prognosis.

Methods

MUNIX measures were recorded from the bilateral zygomaticus, orbicularis oculi, and orbicularis oris muscles of 10 healthy individuals and 64 patients with Bell's palsy. The patients were assessed by two specialist neurologists using the House–Brackmann and Sunnybrook Facial Grading Systems. Repeat assessments were performed on 20 patients with Bell's palsy who received treatment. Additionally, the 64 patients were reassessed using clinical scales after a 1-month interval.

Results

The MUNIX values of the main affected muscles on the affected side were lower than those on the healthy side in patients with Bell's palsy (p < .05). The MUNIX measurements significantly correlated with the clinical facial nerve palsy scale scores (p < .05). Significant improvements were observed in the MUNIX values on repeat testing following treatment (p < .05). The baseline motor unit size index (the compound muscle action potential amplitude divided by MUNIX) was positively associated with improved clinical presentation after 1 month (p < .05).

Conclusion

MUNIX can be used as an electrophysiological biomarker for the quantitative assessment of facial nerve palsy and treatment response, and as a prognostic biomarker, in patients with early Bell's palsy, and is recommended as a complement to conventional neurophysiological examinations.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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