Yixiao Wang, Fengyuan Zhang, Li Xu, Xiaohong Ji, Shanshan Wang, Xiao Shen, Haiyan Chen, Shengyuan Jiang, Chengqian Wu, Min Chen, Hong Yu
{"title":"类风湿性关节炎与不良妊娠结局的因果关系：孟德尔随机化的遗传证据","authors":"Yixiao Wang, Fengyuan Zhang, Li Xu, Xiaohong Ji, Shanshan Wang, Xiao Shen, Haiyan Chen, Shengyuan Jiang, Chengqian Wu, Min Chen, Hong Yu","doi":"10.1111/aji.13922","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Objective</h3>\n \n <p>Although the association of rheumatoid arthritis (RA) to multiple adverse pregnancy outcomes has been well-studied, the association between serum antibody levels in patients with RA and multiple adverse pregnancy outcomes has not been conclusively demonstrated. Here, we comprehensively assessed the causal impact of RA, serologic antibody-positive RA (pRA), and serologic antibody-negative RA (nRA) on the risk of 14 adverse pregnancy outcomes.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The causal impact of RA, pRA, and nRA on 14 adverse pregnancy outcomes was comprehensively assessed using two-sample Mendelian randomization (MR). Evidence maps based on the results of these two-sample MR analyses were developed. Data from the UK Biobank and FinnGen databases were utilized for this analysis. The inverse variance weighted (IVW) test was employed as the primary method to estimate causality. “TwoSampleMR” and “MR-PRESSO” packages were used for data analysis in this study.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Using two-sample MR analysis, we found a significant positive causal association between RA and increased risk of cesarean section (<i>p</i> = 0.003), gestational hypertension (<i>p</i> < 0.001), number of spontaneous miscarriages (<i>p</i> = 0.041), preeclampsia (<i>p</i> = 0.008), premature rupture of membranes (<i>p</i> = 0.030), and preterm (<i>p</i> = 0.010). pRA had a significant positive causal association with an increased risk of cesarean section (<i>p</i> = 0.012), gestational hypertension (<i>p</i> < 0.001), preeclampsia (<i>p</i> = 0.002), and preterm (<i>p</i> = 0.007). A significant positive causal association was also established between nRA and gestational hypertension (<i>p</i> = 0.010), the number of spontaneous miscarriages (<i>p</i> = 0.024), and placental abruption (<i>p</i> = 0.027). In addition, we found a causal association between nRA and birth weight (<i>p</i> = 0.007), but not between RA and pRA and birth weight.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The results of this study have important implications for the individualized treatment of RA patients, especially those with positive serum antibody levels.</p>\n </section>\n </div>","PeriodicalId":7665,"journal":{"name":"American Journal of Reproductive Immunology","volume":"92 3","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Causal Association of Rheumatoid Arthritis With Adverse Pregnancy Outcomes: Genetic Evidence From Mendelian Randomization\",\"authors\":\"Yixiao Wang, Fengyuan Zhang, Li Xu, Xiaohong Ji, Shanshan Wang, Xiao Shen, Haiyan Chen, Shengyuan Jiang, Chengqian Wu, Min Chen, Hong Yu\",\"doi\":\"10.1111/aji.13922\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p>Although the association of rheumatoid arthritis (RA) to multiple adverse pregnancy outcomes has been well-studied, the association between serum antibody levels in patients with RA and multiple adverse pregnancy outcomes has not been conclusively demonstrated. Here, we comprehensively assessed the causal impact of RA, serologic antibody-positive RA (pRA), and serologic antibody-negative RA (nRA) on the risk of 14 adverse pregnancy outcomes.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>The causal impact of RA, pRA, and nRA on 14 adverse pregnancy outcomes was comprehensively assessed using two-sample Mendelian randomization (MR). Evidence maps based on the results of these two-sample MR analyses were developed. Data from the UK Biobank and FinnGen databases were utilized for this analysis. The inverse variance weighted (IVW) test was employed as the primary method to estimate causality. “TwoSampleMR” and “MR-PRESSO” packages were used for data analysis in this study.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Using two-sample MR analysis, we found a significant positive causal association between RA and increased risk of cesarean section (<i>p</i> = 0.003), gestational hypertension (<i>p</i> < 0.001), number of spontaneous miscarriages (<i>p</i> = 0.041), preeclampsia (<i>p</i> = 0.008), premature rupture of membranes (<i>p</i> = 0.030), and preterm (<i>p</i> = 0.010). pRA had a significant positive causal association with an increased risk of cesarean section (<i>p</i> = 0.012), gestational hypertension (<i>p</i> < 0.001), preeclampsia (<i>p</i> = 0.002), and preterm (<i>p</i> = 0.007). A significant positive causal association was also established between nRA and gestational hypertension (<i>p</i> = 0.010), the number of spontaneous miscarriages (<i>p</i> = 0.024), and placental abruption (<i>p</i> = 0.027). 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Causal Association of Rheumatoid Arthritis With Adverse Pregnancy Outcomes: Genetic Evidence From Mendelian Randomization
Objective
Although the association of rheumatoid arthritis (RA) to multiple adverse pregnancy outcomes has been well-studied, the association between serum antibody levels in patients with RA and multiple adverse pregnancy outcomes has not been conclusively demonstrated. Here, we comprehensively assessed the causal impact of RA, serologic antibody-positive RA (pRA), and serologic antibody-negative RA (nRA) on the risk of 14 adverse pregnancy outcomes.
Methods
The causal impact of RA, pRA, and nRA on 14 adverse pregnancy outcomes was comprehensively assessed using two-sample Mendelian randomization (MR). Evidence maps based on the results of these two-sample MR analyses were developed. Data from the UK Biobank and FinnGen databases were utilized for this analysis. The inverse variance weighted (IVW) test was employed as the primary method to estimate causality. “TwoSampleMR” and “MR-PRESSO” packages were used for data analysis in this study.
Results
Using two-sample MR analysis, we found a significant positive causal association between RA and increased risk of cesarean section (p = 0.003), gestational hypertension (p < 0.001), number of spontaneous miscarriages (p = 0.041), preeclampsia (p = 0.008), premature rupture of membranes (p = 0.030), and preterm (p = 0.010). pRA had a significant positive causal association with an increased risk of cesarean section (p = 0.012), gestational hypertension (p < 0.001), preeclampsia (p = 0.002), and preterm (p = 0.007). A significant positive causal association was also established between nRA and gestational hypertension (p = 0.010), the number of spontaneous miscarriages (p = 0.024), and placental abruption (p = 0.027). In addition, we found a causal association between nRA and birth weight (p = 0.007), but not between RA and pRA and birth weight.
Conclusion
The results of this study have important implications for the individualized treatment of RA patients, especially those with positive serum antibody levels.
期刊介绍：
The American Journal of Reproductive Immunology is an international journal devoted to the presentation of current information in all areas relating to Reproductive Immunology. The journal is directed toward both the basic scientist and the clinician, covering the whole process of reproduction as affected by immunological processes. The journal covers a variety of subspecialty topics, including fertility immunology, pregnancy immunology, immunogenetics, mucosal immunology, immunocontraception, endometriosis, abortion, tumor immunology of the reproductive tract, autoantibodies, infectious disease of the reproductive tract, and technical news.
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