额颞叶变性患者纹状体多巴胺转运体结合力明显减弱，MAPT N279K突变早在前驱期就已出现，但无帕金森病症状

IF 3.1 3区医学 Q2 CLINICAL NEUROLOGY

Parkinsonism & related disorders Pub Date : 2024-09-08 DOI:10.1016/j.parkreldis.2024.107144

Toji Miyagawa, Cynthia Vernon, Scott A. Przybelski, Paul H. Min, Julie A. Fields, Bradford C. Dickerson, Dennis W. Dickson, Kejal Kantarci, Val J. Lowe, Zbigniew K. Wszolek, Bradley F. Boeve

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引用次数: 0

摘要

我们的研究发现，通过对三例 MAPT N279K 突变的家族性额颞叶痴呆（fFTD）患者的 123I-FP-CIT SPECT 扫描，以及类似的额颞叶变性伴黑质神经元严重缺失的尸检结果，发现多巴胺转运体结合力的显著下降（z-score <-5.0）出现在无帕金森病的前驱期 fFTD。

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Prominent loss of striatal dopamine transporter binding in frontotemporal lobar degeneration with the MAPT N279K mutation present as early as at prodromal stage without parkinsonism

Our research found out, from ¹²³I-FP-CIT SPECT scans of three familial frontotemporal dementia (fFTD) individuals with MAPT N279K mutation and similar autopsy findings of frontotemporal degeneration with severe neuronal loss in the substantia nigra, that prominent decrease of dopamine transporter binding (z-score < −5.0) was present at prodromal fFTD without parkinsonism.

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来源期刊

Parkinsonism & related disorders 医学-临床神经学

CiteScore

6.20

自引率

4.90%

发文量

292

审稿时长

39 days

期刊介绍： Parkinsonism & Related Disorders publishes the results of basic and clinical research contributing to the understanding, diagnosis and treatment of all neurodegenerative syndromes in which Parkinsonism, Essential Tremor or related movement disorders may be a feature. Regular features will include: Review Articles, Point of View articles, Full-length Articles, Short Communications, Case Reports and Letter to the Editor.