基于 3-溴-4-羟基-7-甲氧基喹啉-2-酮的噁硫平、苯并[b][1, 4]噻嗪和喹啉-4-醇衍生物的设计、合成和结构研究

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2024-09-03 DOI:10.1080/00397911.2024.2397814

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引用次数: 0

摘要

4-羟基-7-甲氧基喹啉-2-酮（1）及其衍生物 3-溴-4-羟基-7-甲氧基喹啉-2-酮（2）是合成高级杂化合物的重要中间体。化合物 (2) 的反应活性已通过多种取代反应得到验证。它们与 2-巯基乙酸、3-巯基丙酸或 2-氨基苯甲酸反应，以较高的产率合成了相应的杂化合物。合成的化合物通过元素分析和光谱分析进行了全面检验。此外，DFT 计算根据光谱研究证实了它们的结构。此外，研究还深入探讨了全局化学反应性参数。

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Design, synthesis and structural studies of oxathiepine, benzo[b][1, 4]thiazine and quinolin-4-ol derivative based on 3-bromo-4-hydroxy-7-methoxyquinolin-2-one

4-Hydroxy-7-methoxyquinolin-2-one (1) and its derivative 3-bromo-4-hydroxy-7-methoxyquinolin-2-one (2) serve as valuable intermediates for the synthesis of advanced hetero-compounds. The reactivity of compound (2) has been verified through multiple substitution reactions. Their reactions with 2-mercaptoacetic acid, 3-mercaptopropanoic acid, or 2-aminobenzoic acid resulted in the corresponding hetero-compounds with high yields. The synthesized compounds underwent thorough examination via elemental and spectral analyses. Additionally, DFT calculations confirmed their structures in accordance with spectral investigations. Furthermore, the study delved into the global chemical reactivity parameters.

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.