利用铃木偶联反应短步合成四氯乙烯和芳基硼酸中的不对称乙炔以及改进温和的脱氯反应

IF 1.4 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Chemistry Letters Pub Date : 2024-08-14 DOI:10.1093/chemle/upae079

Hiyono Suzuki, Akane Togo, Junya Kikuzawa, Kazuki Miyamoto, Shinsuke Marumoto, Akiko Kuwabara, Masafumi Kobayashi, Kouichi Matsumoto

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引用次数: 0

摘要

开发了以四氯乙烯和芳基硼酸为原料短步合成不对称炔烃的方法，并使用金属镁作为温和的脱氯试剂。包括供体和受体二芳基乙炔在内的不对称乙炔都以良好的收率生成。本文研究了该步骤的反应优化、范围和限制、放大反应和评估。

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Short steps synthesis of unsymmetrical acetylenes from tetrachloroethylene and arylboronic acids using Suzuki coupling reaction and improvement of mild dechlorinations

Short steps synthesis of unsymmetrical acetylenes from tetrachloroethylene and arylboronic acids, and the use of the metal Mg as the mild reagent for dechlorinations has been developed. Unsymmetrical acetylenes including the donor and acceptor diarylacetylenes were produced in good yields. The reaction optimization, scope and limitations, the scale-up reaction, and the evaluation of the step were studied for this paper.

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来源期刊

Chemistry Letters 化学-化学综合

CiteScore

3.00

自引率

6.20%

发文量

260

审稿时长

1.2 months

期刊介绍： Chemistry Letters covers the following topics: -Organic Chemistry- Physical Chemistry- Inorganic Chemistry- Analytical Chemistry- Materials Chemistry- Polymer Chemistry- Supramolecular Chemistry- Organometallic Chemistry- Coordination Chemistry- Biomolecular Chemistry- Natural Products and Medicinal Chemistry- Electrochemistry