Ekaterina Shabratova, Hadi Lotfi, Ayman Sakr, Mohamed Atef Hassan, Michal Kern, Matthias Neeb, René Grüneberger, Bastian Klemke, Gianluca Marcozzi, Klaus Kiefer, Aleksei Tsarapkin, Katja Höflich, Alina Dittwald, Andrea Denker, Jens Anders, Joseph E. McPeak, Klaus Lips
{"title":"开发用于在 X 射线吸收光谱分析过程中监测辐射损伤的片上 EPR 光谱仪","authors":"Ekaterina Shabratova, Hadi Lotfi, Ayman Sakr, Mohamed Atef Hassan, Michal Kern, Matthias Neeb, René Grüneberger, Bastian Klemke, Gianluca Marcozzi, Klaus Kiefer, Aleksei Tsarapkin, Katja Höflich, Alina Dittwald, Andrea Denker, Jens Anders, Joseph E. McPeak, Klaus Lips","doi":"10.1007/s00723-024-01702-7","DOIUrl":null,"url":null,"abstract":"<p>Electron paramagnetic resonance (EPR) spectroscopy is an essential tool to investigate the effects of ionizing radiation, which is routinely administered for reducing contaminations and waste in food products and cosmetics as well as for sterilization in industry and medicine. In materials research, EPR methods are not only employed as a spectroscopic method of structural investigations, but also have been employed for detection of changes in electronic structure due to radiation damage from high energy X-rays, for example, to monitor radical formation inside biomolecules caused by X-ray irradiation at carbon, nitrogen, and oxygen K-edges at synchrotron facilities. Here a compact EPR spectrometer, based on EPR-on-a-chip (EPRoC) sensor and a portable electromagnet, has been developed as a solution for monitoring radiation damage of samples during their investigation by X-ray absorption spectroscopy (XAS) at synchrotron facilities. A portable electromagnet with a soft iron core and forced air temperature stabilization was constructed as the source of the external magnetic field. The sweep range of magnetic field inside the most homogeneous region of the portable electromagnet is 12–290 mT. The compact spectrometer performance was evaluated by placing the EPRoC sensor inside either a commercial electromagnet or the portable electromagnet to record the EPR spectrum of tempol, irradiated alanine, and dilithium phthalocyanine (Li<sub>2</sub>Pc). The potential performance of the portable spectrometer for the detection of radiation damage in organic compounds and transition metal-containing catalysts during XAS measurements in both fluorescence and transmission modes was calculated with promising implications for measurements after implementation in a synchrotron-based XAS spectrometer.</p>","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"4 1","pages":""},"PeriodicalIF":1.1000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Towards an EPR on a Chip Spectrometer for Monitoring Radiation Damage During X-ray Absorption Spectroscopy\",\"authors\":\"Ekaterina Shabratova, Hadi Lotfi, Ayman Sakr, Mohamed Atef Hassan, Michal Kern, Matthias Neeb, René Grüneberger, Bastian Klemke, Gianluca Marcozzi, Klaus Kiefer, Aleksei Tsarapkin, Katja Höflich, Alina Dittwald, Andrea Denker, Jens Anders, Joseph E. McPeak, Klaus Lips\",\"doi\":\"10.1007/s00723-024-01702-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Electron paramagnetic resonance (EPR) spectroscopy is an essential tool to investigate the effects of ionizing radiation, which is routinely administered for reducing contaminations and waste in food products and cosmetics as well as for sterilization in industry and medicine. In materials research, EPR methods are not only employed as a spectroscopic method of structural investigations, but also have been employed for detection of changes in electronic structure due to radiation damage from high energy X-rays, for example, to monitor radical formation inside biomolecules caused by X-ray irradiation at carbon, nitrogen, and oxygen K-edges at synchrotron facilities. Here a compact EPR spectrometer, based on EPR-on-a-chip (EPRoC) sensor and a portable electromagnet, has been developed as a solution for monitoring radiation damage of samples during their investigation by X-ray absorption spectroscopy (XAS) at synchrotron facilities. A portable electromagnet with a soft iron core and forced air temperature stabilization was constructed as the source of the external magnetic field. The sweep range of magnetic field inside the most homogeneous region of the portable electromagnet is 12–290 mT. The compact spectrometer performance was evaluated by placing the EPRoC sensor inside either a commercial electromagnet or the portable electromagnet to record the EPR spectrum of tempol, irradiated alanine, and dilithium phthalocyanine (Li<sub>2</sub>Pc). The potential performance of the portable spectrometer for the detection of radiation damage in organic compounds and transition metal-containing catalysts during XAS measurements in both fluorescence and transmission modes was calculated with promising implications for measurements after implementation in a synchrotron-based XAS spectrometer.</p>\",\"PeriodicalId\":469,\"journal\":{\"name\":\"Applied Magnetic Resonance\",\"volume\":\"4 1\",\"pages\":\"\"},\"PeriodicalIF\":1.1000,\"publicationDate\":\"2024-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Magnetic Resonance\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://doi.org/10.1007/s00723-024-01702-7\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSICS, ATOMIC, MOLECULAR & CHEMICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Magnetic Resonance","FirstCategoryId":"101","ListUrlMain":"https://doi.org/10.1007/s00723-024-01702-7","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, ATOMIC, MOLECULAR & CHEMICAL","Score":null,"Total":0}
引用次数: 0
摘要
电子顺磁共振(EPR)光谱是研究电离辐射影响的重要工具,电离辐射通常用于减少食品和化妆品中的污染和废物,以及工业和医学中的消毒。在材料研究中,EPR 方法不仅被用作结构研究的光谱方法,还被用于检测高能 X 射线辐射损伤导致的电子结构变化,例如,监测同步加速器设施中碳、氮和氧 K 边缘 X 射线辐照导致的生物大分子内部自由基的形成。在此,我们开发了一种基于片上 EPR(EPRoC)传感器和便携式电磁铁的紧凑型 EPR 光谱仪,作为在同步辐射设施中使用 X 射线吸收光谱(XAS)研究样品时监测辐射损伤的解决方案。我们制作了一个带有软铁芯和强制空气温度稳定装置的便携式电磁铁作为外部磁场源。便携式电磁铁最均匀区域内的磁场扫描范围为 12-290 mT。通过将 EPRoC 传感器置于商用电磁铁或便携式电磁铁内,记录 tempol、辐照丙氨酸和酞菁二锂(Li2Pc)的 EPR 光谱,对紧凑型光谱仪的性能进行了评估。计算了便携式光谱仪在荧光和透射两种 XAS 测量模式下检测有机化合物和含过渡金属催化剂中辐射损伤的潜在性能,并对在同步加速器 XAS 光谱仪中实施后的测量提出了很好的建议。
Towards an EPR on a Chip Spectrometer for Monitoring Radiation Damage During X-ray Absorption Spectroscopy
Electron paramagnetic resonance (EPR) spectroscopy is an essential tool to investigate the effects of ionizing radiation, which is routinely administered for reducing contaminations and waste in food products and cosmetics as well as for sterilization in industry and medicine. In materials research, EPR methods are not only employed as a spectroscopic method of structural investigations, but also have been employed for detection of changes in electronic structure due to radiation damage from high energy X-rays, for example, to monitor radical formation inside biomolecules caused by X-ray irradiation at carbon, nitrogen, and oxygen K-edges at synchrotron facilities. Here a compact EPR spectrometer, based on EPR-on-a-chip (EPRoC) sensor and a portable electromagnet, has been developed as a solution for monitoring radiation damage of samples during their investigation by X-ray absorption spectroscopy (XAS) at synchrotron facilities. A portable electromagnet with a soft iron core and forced air temperature stabilization was constructed as the source of the external magnetic field. The sweep range of magnetic field inside the most homogeneous region of the portable electromagnet is 12–290 mT. The compact spectrometer performance was evaluated by placing the EPRoC sensor inside either a commercial electromagnet or the portable electromagnet to record the EPR spectrum of tempol, irradiated alanine, and dilithium phthalocyanine (Li2Pc). The potential performance of the portable spectrometer for the detection of radiation damage in organic compounds and transition metal-containing catalysts during XAS measurements in both fluorescence and transmission modes was calculated with promising implications for measurements after implementation in a synchrotron-based XAS spectrometer.
期刊介绍:
Applied Magnetic Resonance provides an international forum for the application of magnetic resonance in physics, chemistry, biology, medicine, geochemistry, ecology, engineering, and related fields.
The contents include articles with a strong emphasis on new applications, and on new experimental methods. Additional features include book reviews and Letters to the Editor.