光子计数探测器 CT 扫描的虚拟非对比重建在评估腹部器官方面的可靠性

IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Ibolyka Dudás, Leona Schultz, Márton Benke, Ákos Szücs, Pál Novák Kaposi, Attila Szijártó, Pál Maurovich-Horvat, Bettina Katalin Budai
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引用次数: 0

摘要

光子计数探测器 CT(PCD-CT)扫描仪的光谱成像可生成虚拟非对比度(VNC)重建。通过分析 12 个腹部器官,我们旨在测试 VNC 重建与真实未增强 CT 图像相比在保留 HU 值方面的可靠性。我们的研究包括 34 名胰腺囊性肿瘤(PCN)患者。VNC 重建是使用 Liver-VNC 算法从未增强、动脉、门脉和静脉相 PCD-CT 扫描中生成的。观察到的 11 个腹部器官采用 TotalSegmentator 算法进行分割,PCN 则采用人工分割。从未增强扫描(HUunenhanced)、对比后扫描(HUpostcontrast)和 VNC 重建(HUVNC)中提取平均密度。误差计算公式为:HUerror=HUVNC-HUunenhanced。皮尔逊或斯皮尔曼相关性用于评估相关性。再现性通过类内相关系数(ICC)进行评估。在脊椎、脊柱旁肌肉、肝脏和脾脏中,HU 增强与 HUVNC[未增强]之间存在显著差异。除脾脏(r = 0.45)和肾脏(r = 0.78 和 0.73)外,HUVNC[未增强]与 HUunenhanced 在所有器官中都显示出很强的相关性。在所有对比后阶段,除脾脏和肾脏外,所有器官的 HUVNC 与 HUunenhanced 都有很强的相关性。在肌肉和椎骨中,HUerror 与 HUunenhanced 有显著相关性;在所有对比后阶段,脾脏、椎骨和脊柱旁肌肉与 HUpostcontrast 有显著相关性。除脊椎(ICC:0.17)、脊柱旁肌肉(ICC:0.64-0.79)、脾脏(ICC:0.21-0.47)和肾脏(ICC:0.10-0.31)外,在 ICC 分析期间,所有器官都至少有一个对比后 VNC 重构与 HU 增强显示出良好到极佳的一致性。VNC 重建在大多数器官的至少一个对比后阶段是可靠的,但在利用 VNC 检查脾脏、肾脏和脊椎骨之前还需要进一步改进。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The reliability of virtual non-contrast reconstructions of photon-counting detector CT scans in assessing abdominal organs
Spectral imaging of photon-counting detector CT (PCD-CT) scanners allows for generating virtual non-contrast (VNC) reconstruction. By analyzing 12 abdominal organs, we aimed to test the reliability of VNC reconstructions in preserving HU values compared to real unenhanced CT images. Our study included 34 patients with pancreatic cystic neoplasm (PCN). The VNC reconstructions were generated from unenhanced, arterial, portal, and venous phase PCD-CT scans using the Liver-VNC algorithm. The observed 11 abdominal organs were segmented by the TotalSegmentator algorithm, the PCNs were segmented manually. Average densities were extracted from unenhanced scans (HUunenhanced), postcontrast (HUpostcontrast) scans, and VNC reconstructions (HUVNC). The error was calculated as HUerror=HUVNC–HUunenhanced. Pearson’s or Spearman’s correlation was used to assess the association. Reproducibility was evaluated by intraclass correlation coefficients (ICC). Significant differences between HUunenhanced and HUVNC[unenhanced] were found in vertebrae, paraspinal muscles, liver, and spleen. HUVNC[unenhanced] showed a strong correlation with HUunenhanced in all organs except spleen (r = 0.45) and kidneys (r = 0.78 and 0.73). In all postcontrast phases, the HUVNC had strong correlations with HUunenhanced in all organs except the spleen and kidneys. The HUerror had significant correlations with HUunenhanced in the muscles and vertebrae; and with HUpostcontrast in the spleen, vertebrae, and paraspinal muscles in all postcontrast phases. All organs had at least one postcontrast VNC reconstruction that showed good-to-excellent agreement with HUunenhanced during ICC analysis except the vertebrae (ICC: 0.17), paraspinal muscles (ICC: 0.64–0.79), spleen (ICC: 0.21–0.47), and kidneys (ICC: 0.10–0.31). VNC reconstructions are reliable in at least one postcontrast phase for most organs, but further improvement is needed before VNC can be utilized to examine the spleen, kidneys, and vertebrae.
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来源期刊
BMC Medical Imaging
BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
4.60
自引率
3.70%
发文量
198
审稿时长
27 weeks
期刊介绍: BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.
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