真菌次级代谢的表观遗传调控

IF 4.2 2区生物学 Q2 MICROBIOLOGY

Journal of Fungi Pub Date : 2024-09-13 DOI:10.3390/jof10090648

Yufei Zhang, Wenbin Yu, Yi Lu, Yichuan Wu, Zhiwei Ouyang, Yayi Tu, Bin He

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引用次数: 0

摘要

次生代谢是真菌适应生存环境、促进生存和繁殖的重要机制之一。最近的研究表明，DNA甲基化、组蛋白修饰和非编码RNA等表观遗传调控在真菌次生代谢中起着关键作用，影响着真菌的生长、存活和致病性。本综述介绍了真菌次生代谢表观遗传调控研究的最新进展。我们讨论了表观遗传标记如何对环境变化做出反应并刺激真菌产生具有生物活性的化合物，以及将这些新发现应用于开发新的抗真菌策略和优化次生代谢的可行性。此外，我们还讨论了这一领域未来可能的研究方向。深入了解表观遗传调控网络是未来研究的重点。

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Epigenetic Regulation of Fungal Secondary Metabolism

Secondary metabolism is one of the important mechanisms by which fungi adapt to their living environment and promote survival and reproduction. Recent studies have shown that epigenetic regulation, such as DNA methylation, histone modifications, and non-coding RNAs, plays key roles in fungal secondary metabolism and affect fungal growth, survival, and pathogenicity. This review describes recent advances in the study of epigenetic regulation of fungal secondary metabolism. We discuss the way in which epigenetic markers respond to environmental changes and stimulate the production of biologically active compounds by fungi, and the feasibility of these new findings applied to develop new antifungal strategies and optimize secondary metabolism. In addition, we have deliberated on possible future directions of research in this field. A deeper understanding of epigenetic regulatory networks is a key focus for future research.

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来源期刊

Journal of Fungi Medicine-Microbiology (medical)

CiteScore

6.70

自引率

14.90%

发文量

1151

审稿时长

11 weeks

期刊介绍： Journal of Fungi (ISSN 2309-608X) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to pathogenic fungi, fungal biology, and all other aspects of fungal research. The journal publishes reviews, regular research papers, and communications in quarterly issues. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on paper length. Full experimental details must be provided so that the results can be reproduced.