肠道短链脂肪酸在帕金森病中的作用

IF 1.6 4区 医学 Q3 CLINICAL NEUROLOGY
Mohamed J. Saadh, Anfal Nabeel Mustafa, Mohammed Ahmed Mustafa, Renuka Jyothi. S, Hasan Khalid Dabis, G. V. Siva Prasad, Imad Jassim Mohammad, Ahmed Adnan, Ameer Hassan Idan
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引用次数: 0

摘要

本文研究了短链脂肪酸(SCFA)在帕金森病(PD)中的新功能。肠道微生物群发酵膳食纤维产生的 SCFAs 与肠道-大脑轴的功能障碍和神经炎症有关。这些过程与帕金森病的发展密不可分。本文通过广泛的文献综述,探讨了 SCFAs 在治疗帕金森病方面的潜在治疗意义,包括其调节胃肠道通透性、神经炎症和神经元存活的能力。总体而言,本文强调了 SCFAs 作为调理和治疗帕金森病靶点的潜在治疗作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The role of gut-derived short-chain fatty acids in Parkinson's disease

The role of gut-derived short-chain fatty acids in Parkinson's disease

The emerging function of short-chain fatty acids (SCFAs) in Parkinson's disease (PD) has been investigated in this article. SCFAs, which are generated via the fermentation of dietary fiber by gut microbiota, have been associated with dysfunction of the gut-brain axis and, neuroinflammation. These processes are integral to the development of PD. This article examines the potential therapeutic implications of SCFAs in the management of PD, encompassing their capacity to modulate gastrointestinal permeability, neuroinflammation, and neuronal survival, by conducting an extensive literature review. As a whole, this article emphasizes the potential therapeutic utility of SCFAs as targets for the management and treatment of PD.

Graphical abstract

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来源期刊
Neurogenetics
Neurogenetics 医学-临床神经学
CiteScore
3.90
自引率
0.00%
发文量
24
审稿时长
6 months
期刊介绍: Neurogenetics publishes findings that contribute to a better understanding of the genetic basis of normal and abnormal function of the nervous system. Neurogenetic disorders are the main focus of the journal. Neurogenetics therefore includes findings in humans and other organisms that help understand neurological disease mechanisms and publishes papers from many different fields such as biophysics, cell biology, human genetics, neuroanatomy, neurochemistry, neurology, neuropathology, neurosurgery and psychiatry. All papers submitted to Neurogenetics should be of sufficient immediate importance to justify urgent publication. They should present new scientific results. Data merely confirming previously published findings are not acceptable.
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