开发预防 SARS-CoV-2 感染的自组装纳米粒子疫苗的策略

IF 5.7 2区医学 Q1 IMMUNOLOGY

Frontiers in Immunology Pub Date : 2024-09-11 DOI:10.3389/fimmu.2024.1392898

Kaiwen Yang, Youqin Zeng, Xinyu Wu, Jia Li, Jinlin Guo

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引用次数: 0

摘要

在最近 SARS-CoV-2 爆发的历史中，疫苗一直是重要的公共卫生工具，在有效预防感染方面发挥了重要作用。然而，如何在提高疗效的同时最大限度地减少副作用仍然是一项重大挑战。近年来，人们对基于纳米颗粒的递送系统越来越感兴趣，其目的是提高抗原递送效率和免疫原性。其中，具有不同尺寸、形状和表面特性的自组装纳米粒子受到了广泛关注。本文回顾了利用自组装材料设计和开发 SARS-CoV-2 疫苗的最新进展，强调了它们在递送病毒免疫原方面的优势。此外，我们还简要讨论了设计广谱通用疫苗的策略，为应对未来可能出现的传染性沙眼病毒提供了见解和思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Strategies for developing self-assembled nanoparticle vaccines against SARS-CoV-2 infection

In the recent history of the SARS-CoV-2 outbreak, vaccines have been a crucial public health tool, playing a significant role in effectively preventing infections. However, improving the efficacy while minimizing side effects remains a major challenge. In recent years, there has been growing interest in nanoparticle-based delivery systems aimed at improving antigen delivery efficiency and immunogenicity. Among these, self-assembled nanoparticles with varying sizes, shapes, and surface properties have garnered considerable attention. This paper reviews the latest advancements in the design and development of SARS-CoV-2 vaccines utilizing self-assembled materials, highlighting their advantages in delivering viral immunogens. In addition, we briefly discuss strategies for designing a broad-spectrum universal vaccine, which provides insights and ideas for dealing with possible future infectious sarbecoviruses.

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来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.