转甲状腺素淀粉样变性的高级超声心动图评估：突变携带者的早期表型标志物

medRxiv - Cardiovascular Medicine Pub Date : 2024-08-29 DOI:10.1101/2024.08.27.24311875

Lorena Squassante Capeline, Frederico José Neves Mancuso, Gardênia Silva Lobo Oishi, Marly Uellendahl, Fernando Naylor, Acary Souza Bulle Oliveira, Valdir Ambrósio Moises

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引用次数: 0

摘要

背景转甲状腺素心脏淀粉样变性病（ATTR-CA）是一种因转甲状腺素（TTR）基因突变而导致的危及生命的心脏疾病。本研究旨在对射血分数（EF）保留的TTR携带者进行心室整体纵向应变（GLS）和整体环向应变（GCS）以及传统超声心动图测量。

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Advanced Echocardiographic Assessment in Transthyretin Amyloidosis: Early Phenotype Markers in Mutation Carriers

Background Transthyretin cardiac amyloidosis (ATTR-CA) is a life-threatening heart condition due to mutations in the transthyretin (TTR) gene. This study aimed to investigate ventricular global longitudinal strain (GLS) and global circumferential strain (GCS) alongside traditional echocardiographic measures in TTR carries with preserved ejection fraction (EF).

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medRxiv - Cardiovascular Medicine

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