Ziqing Wang, Danielle A Wallace, Brian W Spitzer, Tianyi Huang, Kent Taylor, Jerome I Rotter, Stephen S Rich, Peter Y Liu, Martha L. Daviglus, Lifang Hou, Alberto R Ramos, Sonya Kaur, J Peter Durda, Hector M González, Myriam Fornage, Susan Redline, Carmen R Isasi, Tamar Sofer
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引用次数: 0
摘要
导言：高灵敏度 C 反应蛋白（CRP）的 DNA 甲基化（DNAm）预测指标为评估慢性炎症提供了一种稳定而准确的方法，避开了急性疾病引起的 CRP 蛋白波动。睡眠质量差与炎症（包括血液中 CRP 水平升高）相关，这可能是睡眠不足与代谢、心血管和神经系统疾病相关的原因。我们的研究旨在描述拉美裔社区健康研究（HCHS/SOL）中睡眠健康表型与 CRP 标志物（血液、遗传和表观遗传指标）之间的关系。
Analysis of C-reactive protein omics-measures associates methylation risk score with sleep health and related health outcomes
Introduction DNA methylation (DNAm) predictors of high sensitivity C-reactive protein (CRP) offer a stable and accurate means of assessing chronic inflammation, bypassing the CRP protein fluctuations secondary to acute illness. Poor sleep health is associated with elevated inflammation (including elevated blood CRP levels) which may explain associations of sleep insufficiency with metabolic, cardiovascular and neurological diseases. Our study aims to characterize the relationships among sleep health phenotypes and CRP markers —blood, genetic, and epigenetic indicators— within the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
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