来自南海软珊瑚 Litophyton brassicum 的新 Meroterpenes

IF 4.9 2区医学 Q1 CHEMISTRY, MEDICINAL

Marine Drugs Pub Date : 2024-08-30 DOI:10.3390/md22090392

Xiaoyi Chen, Jiahui Zhang, Jiayu Yang, Bing Li, Te Li, Han Ouyang, Wenhan Lin, Hongyu Hu, Xia Yan, Shan He

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引用次数: 0

摘要

通过对软珊瑚 Litophyton brassicum 的提取物进行化学研究，分离并鉴定了四种新的美拉德萜烯，即黄铜羟基苯醌 A 和 B（1 和 2）、黄铜萘醌 A 和 B（3 和 4），以及两种已知的相关美拉德萜烯（5 和 6）。利用高分辨率电喷雾离子化质谱（HRESIMS）、核磁共振（NMR）光谱以及与文献数据的比较，阐明了这些化合物的结构。评估了所有化合物对六种致病细菌菌株的抗菌活性以及对三种癌细胞株的细胞毒性活性。在细胞毒性试验中，所有化合物在 10 μM 时对 A549、HeLa 和 MDA-MB-231 细胞株均无活性。在抗菌试验中，化合物 1 和 2 表现出中等程度的抑制活性，最低抑制浓度（MIC）为 8 至 64 μg/mL。

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New Meroterpenes from South China Sea Soft Coral Litophyton brassicum

A chemical investigation of the extracts from the soft coral Litophyton brassicum led to the isolation and identification of four new meroterpenes, brassihydroxybenzoquinone A and B (1 and 2) and brassinaphthoquinone A and B (3 and 4), along with two known related meroterpenes (5 and 6). Their structures were elucidated using high-resolution electrospray ionization mass spectrometry (HRESIMS), nuclear magnetic resonance (NMR) spectroscopy, and a comparison with the literature data. All compounds were evaluated for antibacterial activity against six pathogenic bacterial strains and for cytotoxic activity against three cancer cell lines. In the cytotoxic assay, all compounds were inactive at 10 μM against the A549, HeLa, and MDA-MB-231 cell lines. In the antibacterial assay, compounds 1 and 2 exhibited moderate inhibitory activity with minimum inhibitory concentrations (MIC) ranging from 8 to 64 μg/mL.

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来源期刊

Marine Drugs 医学-医药化学

CiteScore

9.60

自引率

14.80%

发文量

671

审稿时长

1 months

期刊介绍： Marine Drugs (ISSN 1660-3397) publishes reviews, regular research papers and short notes on the research, development and production of drugs from the sea. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible, particularly synthetic procedures and characterization information for bioactive compounds. There is no restriction on the length of the experimental section.