纳米载体、表面活性剂系统及其负载机制对改善药物吸收和生物利用率的重要性:综述

IF 1.7 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY
Nazeer Abdul Azeez, Krishnaswami Venkateshwaran, Ruckmani Kandasamy, Muthupandian Saravanan, Vijaykumar Sudarshana Deepa
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引用次数: 0

摘要

改善循环系统吸收不良的难溶性治疗分子的表观溶解度是药物发现领域的一个重要研究课题。提高表观溶解度的方法是通过纳米载体输送药物,纳米载体的表面活性剂可提供表观溶解度。纳米载体的有效性主要取决于其负载效率,而负载效率则取决于药物与载体表面活性剂之间的相互作用程度。只有更好地了解药物与表面活性剂的共轭机理,才能更好地计算载药效率。因此,本综述介绍了不同的纳米载体、其合适的表面活性剂系统以及药物通过不同键与表面活性剂的负载机制。此外,最后还简要总结了纳米载体的现状和前景,阐述了这些纳米载体在给药方面的重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Importance of nano-carriers, surfactant system, and their loading mechanism to improve the absorption and bio-availability of drugs: a review
Improving the apparent solubility of poorly soluble therapeutic molecules with poor absorption into the circulatory system is a significant research question in drug discovery. This enhancement is achieved by delivering drugs through nano-carriers that provide apparent solubility with its surfactant. The effectiveness of a nano-carrier is relied majorly on its loading efficiency which is determined by the extent of interaction between the drug and the surfactants of the carriers. The loading effectiveness can be reckoned with a better understanding of the drug-surfactant conjugation mechanism. Hence this review comprehends the different nano-carriers, their appropriate surfactant systems, and the loading mechanism of drugs with surfactants through different bonds. Further, the current status and prospects of the nano-carriers are briefly summarized at last to expound on the significance of these nano-carriers in drug delivery.
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Advances in Natural Sciences: Nanoscience and Nanotechnology
Advances in Natural Sciences: Nanoscience and Nanotechnology NANOSCIENCE & NANOTECHNOLOGYMATERIALS SCIE-MATERIALS SCIENCE, MULTIDISCIPLINARY
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