尼妥珠单抗加伊匹单抗辅助治疗期间的隐匿性检查点抑制剂心肌炎：一种隐匿但严重的毒性。

IF 2.7 4区医学 Q3 IMMUNOLOGY

Immunotherapy Pub Date : 2024-09-11 DOI:10.1080/1750743x.2024.2385286

Dimitrios Bafaloukos,Ioanna Gazouli,Aikaterini Bousmpoukea,Aristea Molfeta,Eleni Chatzichristou,George Samonis,Ioannis Vathiotis

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引用次数: 0

摘要

检查点抑制剂心肌炎是一种罕见但危及生命的免疫疗法毒性，偶尔表现为肌钙蛋白持续升高。在转移性黑色素瘤患者中，使用伊匹单抗和尼沃单抗的双重检查点阻断疗法可诱发免疫相关性心肌炎。我们在此报告了一例54岁男性患者在接受完全切除的IV期黑色素瘤的辅助治疗后，单次输注nivolumab和ipilimumab后出现的免疫相关性心肌炎。大剂量类固醇治疗导致心肌酶水平下降，但未出现任何重大并发症。

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Occult checkpoint inhibitor myocarditis during adjuvant nivolumab plus ipilimumab: a smoldering but severe toxicity.

Checkpoint inhibitor myocarditis is a rare but life-threatening toxicity of immunotherapy, occasionally manifesting as persistent troponin elevation. Dual checkpoint blockade with ipilimumab and nivolumab has been found to induce immune-related myocarditis in patients with metastatic melanoma. We herein report a case of smoldering immune-related myocarditis in a 54-year-old male after a single infusion of nivolumab plus ipilimumab as adjuvant treatment for completely resected stage IV melanoma. High-dose steroid treatment resulted in decrease in the levels of cardiac enzymes, without any major complications.

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来源期刊

Immunotherapy 医学-免疫学

CiteScore

5.00

自引率

3.60%

发文量

113

审稿时长

6-12 weeks

期刊介绍： Many aspects of the immune system and mechanisms of immunomodulatory therapies remain to be elucidated in order to exploit fully the emerging opportunities. Those involved in the research and clinical applications of immunotherapy are challenged by the huge and intricate volumes of knowledge arising from this fast-evolving field. The journal Immunotherapy offers the scientific community an interdisciplinary forum, providing them with information on the most recent advances of various aspects of immunotherapies, in a concise format to aid navigation of this complex field. Immunotherapy delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for this vitally important area of research. Unsolicited article proposals are welcomed and authors are required to comply fully with the journal''s Disclosure & Conflict of Interest Policy as well as major publishing guidelines, including ICMJE and GPP3.