心脏生物标记物心肌肌钙蛋白 I 的电化学检测

IF 9.7 4区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
VIEW Pub Date : 2024-08-22 DOI:10.1002/viw.20240025
Xiaoyun Qin, Dongyang Li, Xiaomei Qin, Fenghua Chen, Huishi Guo, Yanghai Gui, Jianbo Zhao, Liying Jiang, Dan Luo
{"title":"心脏生物标记物心肌肌钙蛋白 I 的电化学检测","authors":"Xiaoyun Qin, Dongyang Li, Xiaomei Qin, Fenghua Chen, Huishi Guo, Yanghai Gui, Jianbo Zhao, Liying Jiang, Dan Luo","doi":"10.1002/viw.20240025","DOIUrl":null,"url":null,"abstract":"Acute myocardial infarction (AMI) is a major cause of cardiovascular disease-related death. It is essential for patients with cardiovascular disease to receive an early diagnosis of AMI. The most popular technique for the early detection of AMI is the use of biosensors to monitor the concentration of pertinent biomarkers, such as cardiac troponin I (cTnI), in the blood. The electrochemical detection methods hold great promise because of their simplicity, miniaturization, ease of integration, high sensitivity, and rapid response. The prime motive of this review is to present a comprehensive understanding of the pros and cons of methodologies employed for the electrochemical approaches toward the detection of cTnI. A detailed summary is provided for the immunosensors, aptamer sensors, molecular imprinting sensors, and peptide sensors based on various affinity elements. We enumerate the modified electrode materials for electrochemical sensors as well as popular detection techniques. Furthermore, this paper reviews some recent significant advances in point-of-care assays for rapid, accurate detection of cTnI as a smart integrated device for home monitoring. The accumulation of knowledge about these functions will lead to new insights into and concepts for the design of portable miniature sensors for cardiovascular patients at risk of AMI. It is anticipated that the interdisciplinary collaboration can bring more enlightenment to the progress of cardiac biomarkers sensor in the future.","PeriodicalId":34127,"journal":{"name":"VIEW","volume":"65 1","pages":""},"PeriodicalIF":9.7000,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Electrochemical detection of the cardiac biomarker cardiac troponin I\",\"authors\":\"Xiaoyun Qin, Dongyang Li, Xiaomei Qin, Fenghua Chen, Huishi Guo, Yanghai Gui, Jianbo Zhao, Liying Jiang, Dan Luo\",\"doi\":\"10.1002/viw.20240025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Acute myocardial infarction (AMI) is a major cause of cardiovascular disease-related death. It is essential for patients with cardiovascular disease to receive an early diagnosis of AMI. The most popular technique for the early detection of AMI is the use of biosensors to monitor the concentration of pertinent biomarkers, such as cardiac troponin I (cTnI), in the blood. The electrochemical detection methods hold great promise because of their simplicity, miniaturization, ease of integration, high sensitivity, and rapid response. The prime motive of this review is to present a comprehensive understanding of the pros and cons of methodologies employed for the electrochemical approaches toward the detection of cTnI. A detailed summary is provided for the immunosensors, aptamer sensors, molecular imprinting sensors, and peptide sensors based on various affinity elements. We enumerate the modified electrode materials for electrochemical sensors as well as popular detection techniques. Furthermore, this paper reviews some recent significant advances in point-of-care assays for rapid, accurate detection of cTnI as a smart integrated device for home monitoring. The accumulation of knowledge about these functions will lead to new insights into and concepts for the design of portable miniature sensors for cardiovascular patients at risk of AMI. It is anticipated that the interdisciplinary collaboration can bring more enlightenment to the progress of cardiac biomarkers sensor in the future.\",\"PeriodicalId\":34127,\"journal\":{\"name\":\"VIEW\",\"volume\":\"65 1\",\"pages\":\"\"},\"PeriodicalIF\":9.7000,\"publicationDate\":\"2024-08-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"VIEW\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1002/viw.20240025\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"VIEW","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1002/viw.20240025","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
引用次数: 0

摘要

急性心肌梗死(AMI)是心血管疾病相关死亡的主要原因。对心血管疾病患者来说,早期诊断急性心肌梗死至关重要。早期检测急性心肌梗死最常用的技术是使用生物传感器监测血液中相关生物标志物(如心肌肌钙蛋白 I (cTnI))的浓度。电化学检测方法因其简便、微型化、易于集成、灵敏度高和反应迅速而大有可为。本综述的主要目的是全面介绍检测 cTnI 的电化学方法的优缺点。我们详细总结了基于各种亲和元素的免疫传感器、适配体传感器、分子印迹传感器和肽传感器。我们列举了用于电化学传感器的改性电极材料以及流行的检测技术。此外,本文还回顾了近期在床旁检测方面取得的一些重大进展,这些检测方法可快速、准确地检测 cTnI,是一种用于家庭监测的智能集成设备。有关这些功能的知识积累将为针对有急性心肌梗死风险的心血管病人设计便携式微型传感器提供新的见解和概念。预计跨学科合作将为未来心脏生物标志物传感器的发展带来更多启迪。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Electrochemical detection of the cardiac biomarker cardiac troponin I

Electrochemical detection of the cardiac biomarker cardiac troponin I
Acute myocardial infarction (AMI) is a major cause of cardiovascular disease-related death. It is essential for patients with cardiovascular disease to receive an early diagnosis of AMI. The most popular technique for the early detection of AMI is the use of biosensors to monitor the concentration of pertinent biomarkers, such as cardiac troponin I (cTnI), in the blood. The electrochemical detection methods hold great promise because of their simplicity, miniaturization, ease of integration, high sensitivity, and rapid response. The prime motive of this review is to present a comprehensive understanding of the pros and cons of methodologies employed for the electrochemical approaches toward the detection of cTnI. A detailed summary is provided for the immunosensors, aptamer sensors, molecular imprinting sensors, and peptide sensors based on various affinity elements. We enumerate the modified electrode materials for electrochemical sensors as well as popular detection techniques. Furthermore, this paper reviews some recent significant advances in point-of-care assays for rapid, accurate detection of cTnI as a smart integrated device for home monitoring. The accumulation of knowledge about these functions will lead to new insights into and concepts for the design of portable miniature sensors for cardiovascular patients at risk of AMI. It is anticipated that the interdisciplinary collaboration can bring more enlightenment to the progress of cardiac biomarkers sensor in the future.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
VIEW
VIEW Multiple-
CiteScore
12.60
自引率
2.30%
发文量
0
审稿时长
10 weeks
期刊介绍: View publishes scientific articles studying novel crucial contributions in the areas of Biomaterials and General Chemistry. View features original academic papers which go through peer review by experts in the given subject area.View encourages submissions from the research community where the priority will be on the originality and the practical impact of the reported research.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信