编辑评论

IF 2.4 Q2 CLINICAL NEUROLOGY

PRACTICAL NEUROLOGY Pub Date : 2024-10-01 DOI:10.1136/pn-2024-004348

Philip Smith, Geraint N Fuller

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引用次数: 0

摘要

即使是经验丰富的神经科医生，有时也必须从棘手的临床问题中抽身出来，从他们比喻的橱柜中拿出外科筛子，检查自己是否遗漏了什么。筛子提醒我们，除了更常见的解释外，我们还应考虑毒性、环境和代谢原因。本期，弗雷迪-冯伯格（Freddie Vonberg）和彼得-布莱恩（Peter Blain）通过对职业和环境神经毒理学的系统回顾，填补了这些空白（第357页）。神经毒综合征可表现在神经系统的各个层面，从灰质脑病和白质营养不良到肌病和自主神经病变。它们可能在急性或长期接触后出现，因此可能有各种临床时间过程。有些病症有特定的治疗方法，但识别和消除接触对所有病症都至关重要。代谢性疾病很少见，而且越来越多的代谢性疾病是可以治疗的。精氨酸：甘氨酸脒基转移酶缺乏症（第 413 页）的患者就说明了这一点......

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Editors’ commentary

Even experienced neurologists must sometimes step back from a difficult clinical problem, take out the surgical sieve from their metaphorical cupboard, and check they are not missing something. The sieve provides a reminder that alongside the more common explanations we should also consider toxic, environmental and metabolic causes. In this issue, Freddie Vonberg and Peter Blain fill these gaps with a systems-based review of occupational and environmental neurotoxicology (page 357). Neurotoxic syndromes can manifest at all levels of the nervous system, from grey matter encephalopathies and leukodystrophy to myopathies and autonomic neuropathies. They can arise following acute or long-term exposure so may have the full range of clinical time courses. Some have specific treatments, but identifying and removing the exposure is essential for all. Metabolic conditions are rare and an increasing number are treatable. This is illustrated by a patient with arginine:glycine amidinotransferase deficiency (page 413), …

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来源期刊

PRACTICAL NEUROLOGY Medicine-Neurology (clinical)

CiteScore

3.70

自引率

3.60%

发文量

113

期刊介绍： The essential point of Practical Neurology is that it is practical in the sense of being useful for everyone who sees neurological patients and who wants to keep up to date, and safe, in managing them. In other words this is a journal for jobbing neurologists - which most of us are for at least part of our time - who plough through the tension headaches and funny turns week in and week out. Primary research literature potentially relevant to routine clinical practice is far too much for any neurologist to read, let alone understand, critically appraise and assimilate. Therefore, if research is to influence clinical practice appropriately and quickly it has to be digested and provided to neurologists in an informative and convenient way.