使用碱性氧化铝对叔丁氧羰基 (Boc) 进行机械化学脱保护处理

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-09-05 DOI:10.1039/d4ob01091d

Kaidi Tian, Tingna Cai, Zedong Zhu, Kai Cheng, Lemao Yu, Yong Li

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引用次数: 0

摘要

本文介绍了一种无溶剂、操作简单且具有化学选择性的 t-丁氧基羰基（Boc）脱保护机械化学方法。在行星式球磨机中，使用碱性氧化铝可选择性地去除受保护杂环、酰胺和苯胺中的 N-Boc 基团以及碳酸盐中的 O-Boc 基团。这种高产方案避免了繁琐的萃取和柱层析过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mechanochemical deprotection of t-butoxycarbonyl (Boc) group using basic alumina

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Mechanochemical deprotection of t-butoxycarbonyl (Boc) group using basic alumina

A solvent-free, operationally simple, and chemoselective mechanochemical method for t-butoxycarbonyl (Boc) deprotection is described. In a planetary ball mill, N-Boc groups from protected heterocycles, amides, and anilines, as well as O-Boc groups from carbonates, can be removed selectively, using basic alumina. This high-yielding protocol avoids tedious extraction and column chromatography.

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： The international home of synthetic, physical and biomolecular organic chemistry.