代谢综合征对韩国年轻人群心力衰竭的影响：一项全国性研究

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Metabolites Pub Date : 2024-09-04 DOI:10.3390/metabo14090485

Tae-Eun Kim, Do Young Kim, Hyeongsu Kim, Jidong Sung, Duk-Kyung Kim, Myoung-Soon Lee, Seong Woo Han, Hyun-Joong Kim, Hyun Kyun Ki, Sung Hea Kim, Kyu-Hyung Ryu

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引用次数: 0

摘要

关于代谢综合征对年轻人心力衰竭（HF）发展的影响，目前只有有限的数据。利用韩国国民健康保险服务机构的数据，我们纳入了 2009 年 1 月至 2009 年 12 月期间在韩国接受健康检查的 1,958,284 名 40 多岁的受试者。受试者被分为三组：正常、代谢综合征前期（Pre-MetS）和代谢综合征（MetS）。10.58%的男性和5.21%的女性被发现患有代谢综合征。患有代谢综合征的受试者中，男性患高血压的危险比为 1.968（95% CI：1.526-2.539），女性为 2.398（95% CI：1.466-3.923）。对于患有前MetS的患者，男性的危险比为1.607（95% CI：1.293-1.997），女性为1.893（95% CI：1.43-2.505）。此外，急性心肌梗死和低血红蛋白水平也被认为是导致男性和女性患心房颤动的重要风险因素。MetS 使 40 多岁人群罹患心房颤动的风险增加了约一倍。MetS前期也是该人群罹患心房颤动的重要风险因素。

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The Impact of Metabolic Syndrome on Heart Failure in Young Korean Population: A Nationwide Study

Limited data are available regarding the effect of metabolic syndrome on heart failure (HF) development in young individuals. Utilizing data from the Korean National Health Insurance Service, we included a total of 1,958,284 subjects in their 40s who underwent health screening between January 2009 and December 2009 in Korea. Subjects were classified into three groups: normal, pre-metabolic syndrome (Pre-MetS), and metabolic syndrome (MetS). MetS was identified in 10.58% of males and 5.21% of females. The hazard ratio for HF in subjects with MetS was 1.968 (95% CI: 1.526–2.539) for males and 2.398 (95% CI: 1.466–3.923) for females. For those with Pre-MetS, the hazard ratio was 1.607 (95% CI: 1.293–1.997) in males and 1.893 (95% CI: 1.43–2.505) in females. Additionally, acute myocardial infarction and low hemoglobin levels were identified as significant risk factors for HF in both genders. MetS approximately doubled the risk of developing HF in individuals in their 40s. Pre-MetS was also a significant risk factor for HF in this population.

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来源期刊

Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

5.70

自引率

7.30%

发文量

1070

审稿时长

17.17 days

期刊介绍： Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.