中国北方健康人群骨转换生物标志物参考区间的确定

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Lijing Huo, Xuexin Liu, Changmei Wei, Fang Yu, Luping Ren, Yanqing Tie
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引用次数: 0

摘要

目的:本研究旨在确定健康人群骨转换标志物(BTMs)的参考区间:根据美国临床实验室标准协会(CLSI)EP28-A3c标准,我们招募了774名健康中国人,调查了他们的临床特征以及性别、年龄、季节与骨转换标志物之间的关系。通过定义所有观测值的 95% 中心范围,确定了河北省健康人群 BTMs 的参考区间:结果:我们发现性别与 25(OH)D、OC、β-CTX 和 P1NP 相关(P < 0.05),但与 PTH1-84 无关(P=0.138)。所有血清 BTM 在不同年龄组之间均存在差异(P < 0.01)。冬季的 25 (OH) D 水平与春季、夏季和秋季相比存在统计学差异(P< 0.05)。OC水平在夏季和冬季之间存在统计学差异(P=0.000)。P1NP水平在春季和冬季(P=0.019)、夏季和冬季(P=0.000)以及夏季和秋季(P=0.012)之间分别存在统计学差异。冬季的 PTH1-84 水平与春季和夏季相比有统计学差异(均为 P=0.000),而不同季节的 β- CTX 水平差异无统计学意义:我们建立了河北省健康人的几种 BTM 的参考区间,这些参考区间在不同年龄组和性别之间有统计学意义,在不同季节之间也有显著差异。因此,各地的中医实验室应根据不同季节的性别和年龄组进行分组,并建立相应的生物学参考区间:25-羟维生素D 25(OH)D 骨钙素 OC I型胶原β-羧基末端交联端肽 β-CTX I型胶原N-末端原胶原 P1NP 甲状旁腺激素1-84 PTH1-84
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Establishment of Reference Intervals for Bone Turnover Biomarkers in Healthy Populations in Northern China
Aim: This study was intended to establish the reference intervals of bone turnover markers (BTMs) for healthy populations.
Methods: According to the Clinical Laboratory Standards Institute (CLSI) EP28-A3c, we recruited 774 healthy Chinese and investigated their clinical characteristics and relationships among gender, age, season and BTMs. The reference intervals of BTMs for healthy populations in Hebei of China were established through defining the central 95% range of all observations.
Results: We found that gender were associated with 25(OH)D, OC, β-CTX, and P1NP (P < 0.05), but not PTH1-84 (P=0.138). All serum BTMs showed differences among different age groups (P < 0.01). The level of 25 (OH) D in winter showed statistical differences with spring, summer, and autumn (P< 0.05). The OC level showed statistical difference between summer and winter (P=0.000). The P1NP levels showed statistical difference between spring and winter (P=0.019), summer and winter (P=0.000), and summer and autumn (P=0.012), respectively. The PTH1-84 levels in winter showed statistical differences with spring, and summer (all P=0.000), while there was no statistically significant difference in β- CTX levels between seasons.
Conclusion: We have established the reference intervals of several BTMs for healthy individuals in Hebei of China, which have statistical significance across different age groups and genders, and there are also significant differences between different seasons. Therefore, the Chinese medical laboratories in different locations should group individuals according to gender and age groups in different seasons, and establish corresponding biological reference intervals.

Keywords: 25-hydroxyvitamin D, 25(OH)D, osteocalcin, OC, β-carboxy-terminal cross-linking telopeptide of type I collagen, β-CTX, N-terminal procollagen of type I collagen, P1NP, parathyroid hormone 1-84, PTH1-84
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来源期刊
International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
自引率
0.00%
发文量
1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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