L. M. Ermakova, E. A. Davydova, E. V. Kondakova, K. V. Kuchin, M. V. Vedunova
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引用次数: 0
摘要
摘要 心血管疾病仍然是全球最主要的死亡原因，随着年龄的增长，发病风险显著上升。此外，心血管疾病还伴随着循环系统疾病年轻化的现象。目前，表观遗传修饰在心血管疾病（CVD）的成因中起着关键作用，影响着基因型和表型变异之间复杂的相互作用。因此，深入研究表观遗传标记为揭示心血管疾病发病机制的分子基础提供了一条前景广阔的途径。本研究试图找出与心血管系统中与年龄有关的变化密切相关的表观遗传标记。研究显示，两个心血管参数与年龄密切相关：左臂增强导联 R 波张力（RaVL）和颈动脉-股动脉脉搏波速度（cfPWV）。此外，这些参数还与通过 Illumina EPIC 阵列检测的 21 个 CpG 位点（CpGs）的 DNA 甲基化水平密切相关。值得注意的是，这些已确定的 CpG 位点大多与心血管系统病变的相关基因有关。
New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System
Abstract
Cardiovascular diseases remain a predominant global cause of mortality, with a noteworthy rise in the risk of morbidity with advancing age. Besides, it accompanied by a phenomenon of disease rejuvenation in the circulatory system. Currently, epigenetic modifications play a key role in the genesis of cardiovascular diseases (CVD), influencing the complex interaction between genotype and phenotype variability. Consequently, delving into the realm of epigenetic markers offers a promising avenue to unravel the molecular underpinnings of cardiovascular disease pathogenesis. This study endeavors to pinpoint epigenetic markers intricately linked with age-related transformations in the cardiovascular system. The study revealed a robust correlation with age for two cardiological parameters: R wave tension in the augmented left arm lead (RaVL) and carotid-femoral pulse wave velocity (cfPWV). Moreover, these parameters exhibited a strong correlation with the DNA methylation level of 21 CpG-sites (CpGs) examined through the Illumina EPIC array. Notably, the majority of these identified CpG-sites are affiliated with genes involved in the development of pathologies of the cardiovascular system.
期刊介绍：
Molecular Biology is an international peer reviewed journal that covers a wide scope of problems in molecular, cell and computational biology including genomics, proteomics, bioinformatics, molecular virology and immunology, molecular development biology, molecular evolution and related areals. Molecular Biology publishes reviews, experimental and theoretical works. Every year, the journal publishes special issues devoted to most rapidly developing branches of physical-chemical biology and to the most outstanding scientists.
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