化学神经科学经典：麝香草酚

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-09-10 DOI:10.1021/acschemneuro.4c00304

Diego Rivera-Illanes, Gonzalo Recabarren-Gajardo

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引用次数: 0

摘要

Muscimol (3) 是一种具有精神活性的异噁唑，与ibotenic acid 和 muscarine 一起存在于各种天南星蘑菇中。它在结构上与 GABA 有关，是一种 GABAA 激动剂，具有很强的亲和力。麝香草酚的使用可以追溯到西伯利亚的萨满文化，当时人们将其作为一种精神致幻剂，通过口服来产生精神作用。3H麝香草酚被用作 GABA 受体研究中的放射性配体，虽然没有被批准用于临床，但其作为神经科学研究工具的潜力和用途却具有巨大价值。自上世纪 60 年代初发现这种化合物以来，许多研究小组都致力于合成这种化合物。最近的研究表明，麝香草酚可用于缓解神经性疼痛，其他潜在用途也在研究之中。在这篇综述中，我们将介绍这种化合物的历史、化学、药理学和整体重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Classics in Chemical Neuroscience: Muscimol

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Classics in Chemical Neuroscience: Muscimol

Muscimol (3) is a psychoactive isoxazole present in various Amanita mushrooms, along with ibotenic acid and muscarine. It is structurally related to GABA and acts as a GABA_A agonist with great affinity. Muscimol use dates back to Siberian shamanic cultures as an entheogen, where it was ingested orally to exert psychoactive effects. Although not approved for clinical use, its potential and use as a research tool in neuroscience is of immense value, with ³H-muscimol being used as a radioligand in GABA receptor research. Since its discovery in the early 60s, many research groups have worked on the synthesis of the compound. Recent research suggests the potential use of muscimol in neuropathic pain relief and other potential uses are also being studied. In this review, we will cover the history, chemistry, pharmacology and overall importance of the compound.

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.