用于递送对肺炎克雷伯氏菌具有抗菌潜力的类黄酮的纳米结构

Hanne Lazla Rafael de Queiroz Macêdo, Lara Limeira de Oliveira, David Nattan de Oliveira, Karitas Farias Alves Lima, Isabella Macário Ferro Cavalcanti, Luís André de Almeida Campos
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引用次数: 0

摘要

黄酮类化合物是次生代谢物,具有显著的生物活性,包括对肺炎克雷伯氏菌的抗菌特性,肺炎克雷伯氏菌是导致多种严重院内感染的病原体。然而,口服这些化合物面临着相当大的挑战,如生物利用率低和化学性质不稳定。因此,将黄酮类化合物封装在纳米系统中是一种很有前景的策略,可减轻这些限制,防止降解,提高溶解度,在某些情况下还能实现控制和定向释放。不同类型的纳米载体,如聚合物纳米粒子、脂质体和聚合物胶束等,已显示出通过降低所需治疗剂量和减少副作用来提高类黄酮抗菌功效的潜力。此外,纳米技术的进步还能使黄酮类化合物与其他治疗剂共同封装,并开发出能对更多特定刺激做出反应的系统,从而优化治疗效果。在此背景下,本文对有关类黄酮的文献以及用于递送具有抗菌特性的类黄酮抗肺炎克雷伯氏菌的主要纳米载体进行了最新综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanostructures for Delivery of Flavonoids with Antibacterial Potential against Klebsiella pneumoniae
Flavonoids are secondary metabolites that exhibit remarkable biological activities, including antimicrobial properties against Klebsiella pneumoniae, a pathogen responsible for several serious nosocomial infections. However, oral administration of these compounds faces considerable challenges, such as low bioavailability and chemical instability. Thus, the encapsulation of flavonoids in nanosystems emerges as a promising strategy to mitigate these limitations, offering protection against degradation; greater solubility; and, in some cases, controlled and targeted release. Different types of nanocarriers, such as polymeric nanoparticles, liposomes, and polymeric micelles, among others, have shown potential to increase the antimicrobial efficacy of flavonoids by reducing the therapeutic dose required and minimizing side effects. In addition, advances in nanotechnology enable co-encapsulation with other therapeutic agents and the development of systems responsive to more specific stimuli, optimizing treatment. In this context, the present article provides an updated review of the literature on flavonoids and the main nanocarriers used for delivering flavonoids with antibacterial properties against Klebsiella pneumoniae.
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