自体血小板浓缩物作为局部抗生素输送系统的作用:系统性范围界定综述

Roberta Gasparro, Federica Di Spirito, Maria Domenica Campana, Gilberto Sammartino, Alessandro E. di Lauro
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引用次数: 0

摘要

目标:目前正在进行的研究已开始开发创新方法,以输送局部抗生素,同时最大限度地减少全身副作用、抗菌药耐药性和有限的组织穿透力。自体血小板浓缩物(APCs)有望将抗生素直接输送到感染部位。尽管人们对自体血小板浓缩物很感兴趣,但缺乏对其有效性的全面评估。因此,本系统性范围综述旨在收集和评估有关 APCs 输送抗生素疗效的研究。研究方法使用组合关键词对 PubMed、Scopus 和 Web of Science 进行了系统的电子检索,检索期截至 2024 年 2 月。纳入了有关将 APCs 用作局部抗生素递送系统的文章。结果:共筛选出 13 篇文章,包括 10 项体外研究、1 项体外和临床研究、1 项体内外研究和 1 项临床研究。所有研究都证实了多西环素、庆大霉素、利奈唑胺、万古霉素、甲硝唑和青霉素的抗生素负载能力和释放情况。此外,抗菌效果主要针对大肠杆菌、绿脓杆菌、米肠杆菌、流感嗜血杆菌、肺炎双球菌和金黄色葡萄球菌。结论:事实证明,在 APCs 中加入抗生素有助于以最佳浓度有效释放抗菌剂,从而有可能降低术后感染的发生率,替代或加强全身抗生素治疗,同时保留 APCs 固有的愈合特性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Role of Autologous Platelet Concentrates as a Local Antibiotic Delivery System: A Systematic Scoping Review
Objectives: Ongoing research has begun to develop innovative approaches to deliver local antibiotics while minimizing systemic side effects, antimicrobial resistance, and limited tissue penetration. Autologous platelet concentrates (APCs) offer promise in delivering antibiotics directly to infection sites. Despite the interest, a comprehensive evaluation of their effectiveness is lacking. Therefore, this systematic scoping review aims to collect and appraise studies regarding the efficacy of APCs in delivering antibiotics. Methods: A systematic electronic search of PubMed, Scopus, and Web of Science, using a combination of keywords, was conducted up to February 2024. Articles addressing the use of APCs as a local antibiotic delivery system were included. Results: A total of 13 articles, including 10 in vitro studies, 1 in vitro and clinical study, 1 ex vivo study, and 1 clinical study, were selected. Antibiotic loading capacity and release was confirmed in all studies using doxycycline, gentamicin, linezolid, vancomycin, metronidazole, and penicillin. In addition, the antibacterial effect was obtained mainly against E. coli., P. aeruginosa, S. mitis, H. influenzae, S. pneumoniae, and S. aureus. Conclusions: The incorporation of antibiotics into APCs has been proven to facilitate the effective release of antimicrobial agents at optimal concentrations, potentially reducing the incidence of post-operative infections, substituting, or augmenting systemic antibiotic treatment while retaining APCs’ inherent healing properties.
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