Plastrum testudinis 中的 xtr-miR-22-3p 对急性早幼粒细胞白血病的治疗潜力

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2024-08-30 DOI:10.1080/10286020.2024.2395566

Ming-Yang Chen , Meng Li , Qing-Yi Xu , Shu-Wang Zhang , Guang-Xi Ren , Chun-Sheng Liu

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引用次数: 0

摘要

急性早幼粒细胞白血病（APL）的特征是早幼粒细胞阶段的阻滞。ATRA和ATO等治疗方法面临耐药性和复发问题。传统中药 "板蓝根 "可用于治疗急性早幼粒细胞白血病（APL）。

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Therapeutic potential of xtr-miR-22-3p from Plastrum testudinis in acute promyelocytic leukemia

Acute promyelocytic leukemia (APL) is marked by a block at the promyelocyte stage. Treatments like ATRA and ATO face resistance and relapse issues. Plastrum testudinis, a traditional Chinese medicine, may offer therapeutic potential. This study investigated xtr-miR-22-3p from P. testudinis for treating APL. High expression of xtr-miR-22-3p was confirmed, with target prediction indicating interactions with key genes, including PML. xtr-miR-22-3p reduced HL-60 leukemia cell growth, altered the cell cycle, and selectively inhibited HL-60 proliferation while promoting BMSC growth, suggesting its potential as a targeted APL therapy.

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.