生物可吸收性左房阑尾封堵器的动物实验研究

IF 1.2 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Teng Zhao, Fanrong Diao, Zhigang Zhang, Chao Liu, Ying Chen, Yuan Bai, Zhifu Guo, Songqun Huang, Zongjun Liu, Xianxian Zhao, Yongwen Qin, Jiang Cao, Xinmiao Huang
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引用次数: 0

摘要

使用可降解聚合物材料(如聚二氧杂蒽酮(PDO)和聚左旋乳酸(PLA))和镍钛锘丝制成的生物可吸收 LAA 封堵器。成功为18只中国农村犬植入了封堵器,其中2只犬分别因心包填塞和大出血在术后48小时内死亡。经导管 LAA 关闭术后进行了随访观察。术后 2 个月,在封堵器表面发现了新组织。二尖瓣和左上肺静脉等邻近结构没有受到闭塞器圆盘的影响。术后 3 个月时进行了苏木精和伊红(HE)染色,结果显示封堵器表面的内膜结构完好无损,并观察到未被吸收的 PDO 和 PLA。扫描电镜显示内皮细胞排列不规则。术后 6 个月,观察到新的内皮组织完全覆盖了闭塞器。大多数 PDO 被纤维结缔组织取代,扫描电镜显示内皮细胞排列规则。12 个月后的病理检查显示,只有少量的 PDO 残余。由 PDO、聚乳酸和镍钛诺丝制成的生物可吸收 LAA 封堵器可安全有效地封堵狗的 LAA。术后半年,封堵器表面已实现内皮化。封堵器的可吸收材料在一年后降解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Animal Experimental Study of Bioabsorbable Left Atrial Appendage Occluder

Left atrial appendage (LAA) closure can prevent stroke in high-risk patients with atrial fibrillation.

A bioabsorbable LAA occluder made of degradable polymer materials, such as polydioxanone (PDO) and poly-L-lactic acid (PLA), and nitinol wire was used. Occluders were successfully implanted in 18 Chinese rural dogs, 2 of which died within 48 hours after operation due to pericardial tamponade and hemorrhage, respectively. Follow-up observation was performed after transcatheter LAA closure. New tissue was found on the surface of the occluder 2 months after operation. No adjacent structures such as the mitral valve and the left superior pulmonary vein were affected by the occluder discs. Hematoxylin and eosin (HE) staining was performed at 3 months after operation, which showed intact intimal structure on the occluder surface, and unabsorbed PDO and PLA were observed. Scanning electron microscopy showed irregular arrangement of endothelial cells. New endothelial tissue was observed to completely cover the occluder at 6 months after operation. Most PDOs were replaced by fibrous connective tissue, and scanning electron microscopy showed regularly arranged endothelial cells. Pathological examination at 12 months showed only a small remnant of PDO. The gross specimens of the liver, spleen, and kidneys and pathological examination did not indicate thromboembolism.

The bioabsorbable LAA occluder made of PDO, PLA, and nitinol wire was safe and effective for the occlusion of LAA in dogs. The surface of the occluder was endothelialized half a year after operation. The absorbable materials of the occluder were degraded after 1 year.

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来源期刊
International heart journal
International heart journal 医学-心血管系统
CiteScore
2.50
自引率
6.70%
发文量
148
审稿时长
6-12 weeks
期刊介绍: Authors of research articles should disclose at the time of submission any financial arrangement they may have with a company whose product figures prominently in the submitted manuscript or with a company making a competing product. Such information will be held in confidence while the paper is under review and will not influence the editorial decision, but if the article is accepted for publication, the editors will usually discuss with the authors the manner in which such information is to be communicated to the reader.
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