Anne-Marie C Overstreet, McKenzie Burge, Annette Bellar, Megan McMullen, Douglas Czarnecki, Emily Huang, Vai Pathak, Chelsea Finney, Raveena Vij, Srinivasan Dasarathy, Jaividhya Dasarathy, David Streem, Nicole Welch, Daniel Rotroff, Adam M Schmitt, Laura E Nagy, Jeannette S Messer
{"title":"细胞外 HSPB1 促成酒精相关性肝炎炎症的证据","authors":"Anne-Marie C Overstreet, McKenzie Burge, Annette Bellar, Megan McMullen, Douglas Czarnecki, Emily Huang, Vai Pathak, Chelsea Finney, Raveena Vij, Srinivasan Dasarathy, Jaividhya Dasarathy, David Streem, Nicole Welch, Daniel Rotroff, Adam M Schmitt, Laura E Nagy, Jeannette S Messer","doi":"10.1101/2024.09.06.24313193","DOIUrl":null,"url":null,"abstract":"<strong>Background and aims</strong> Alcohol-associated hepatitis (AH) is the most life-threatening form of alcohol-associated liver disease (ALD). AH is characterized by severe inflammation attributed to increased levels of ethanol, microbes or microbial components, and damage-associated molecular pattern (DAMP) molecules in the liver. HSPB1 (Heat Shock Protein Family B (Small) Member 1; also known as Hsp25/27) is a DAMP that is rapidly increased in and released from cells experiencing stress, including hepatocytes. The goal of this study was to define the role of HSPB1 in AH pathophysiology.","PeriodicalId":501258,"journal":{"name":"medRxiv - Gastroenterology","volume":"75 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evidence that extracellular HSPB1 contributes to inflammation in alcohol-associated hepatitis\",\"authors\":\"Anne-Marie C Overstreet, McKenzie Burge, Annette Bellar, Megan McMullen, Douglas Czarnecki, Emily Huang, Vai Pathak, Chelsea Finney, Raveena Vij, Srinivasan Dasarathy, Jaividhya Dasarathy, David Streem, Nicole Welch, Daniel Rotroff, Adam M Schmitt, Laura E Nagy, Jeannette S Messer\",\"doi\":\"10.1101/2024.09.06.24313193\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>Background and aims</strong> Alcohol-associated hepatitis (AH) is the most life-threatening form of alcohol-associated liver disease (ALD). AH is characterized by severe inflammation attributed to increased levels of ethanol, microbes or microbial components, and damage-associated molecular pattern (DAMP) molecules in the liver. HSPB1 (Heat Shock Protein Family B (Small) Member 1; also known as Hsp25/27) is a DAMP that is rapidly increased in and released from cells experiencing stress, including hepatocytes. The goal of this study was to define the role of HSPB1 in AH pathophysiology.\",\"PeriodicalId\":501258,\"journal\":{\"name\":\"medRxiv - Gastroenterology\",\"volume\":\"75 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Gastroenterology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.09.06.24313193\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Gastroenterology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.06.24313193","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Evidence that extracellular HSPB1 contributes to inflammation in alcohol-associated hepatitis
Background and aims Alcohol-associated hepatitis (AH) is the most life-threatening form of alcohol-associated liver disease (ALD). AH is characterized by severe inflammation attributed to increased levels of ethanol, microbes or microbial components, and damage-associated molecular pattern (DAMP) molecules in the liver. HSPB1 (Heat Shock Protein Family B (Small) Member 1; also known as Hsp25/27) is a DAMP that is rapidly increased in and released from cells experiencing stress, including hepatocytes. The goal of this study was to define the role of HSPB1 in AH pathophysiology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
