Advancing Autonomous Nanomedicine: Bridging the Gap from Concept to Potential Clinical Studies

Autonomous nanomedicine, a burgeoning field within nanotechnology and biomedical sciences, is poised to revolutionize healthcare by eliminating the need for external intervention in targeted applications within the body. This article elucidates the promise and challenges of autonomous nanomedicine, emphasizing its ability to overcome the limitations of traditional methods such as chemotherapy and radiotherapy. Central to its efficacy are nano-sized carriers, which autonomously navigate the body to deliver therapeutic agents with precision and control. By integrating automated nanoscale tools into disease detection processes, this technology offers swift and personalized assessments, reshaping disease management paradigms. To advance the clinical translation of autonomous nanomedicine, rigorous preclinical studies are imperative. However, challenges persist in ensuring reproducibility and safety, hindering progress in clinical trials. This article examines current studies with potential clinical translation, shedding light on the regulatory and ethical considerations crucial for its safe implementation. As the field progresses, maintaining a balance between innovation and safety remains paramount for harnessing the full potential of autonomous nanomedicine while safeguarding patient well-being.

Graphical Abstract