端粒动力学是肠道微生物与宿主相互作用的媒介

IF 13 1区生物学 Q1 CELL BIOLOGY

Trends in Cell Biology Pub Date : 2024-09-09 DOI:10.1016/j.tcb.2024.08.003

Michael L. Pepke, Søren B. Hansen, Morten T. Limborg

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引用次数: 0

摘要

高度增殖的肠道组织表现出端粒快速缩短，并对宿主机体产生系统性影响。最近的研究表明，肠道端粒长度动态与肠道微生物组的组成和活性之间存在双向互动，从而将不同脊椎动物物种的炎症、菌群失调和衰老过程联系起来。

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Telomere dynamics as mediators of gut microbiota–host interactions

The highly proliferative gut tissue exhibits rapid telomere shortening with systemic effects on the host organism. Recent studies have demonstrated a bidirectionality in interactions between intestinal telomere length dynamics and the composition and activity of the gut microbiome thus linking processes of inflammation, dysbiosis and aging across different vertebrate species.

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来源期刊

Trends in Cell Biology 生物-细胞生物学

CiteScore

32.00

自引率

0.50%

发文量

160

审稿时长

61 days

期刊介绍： Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.