G. A. Shulmeyster, Yu. D. Chekmeneva, M. A. Baibakova, D. V. Korolev
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Synthesis of Albumin Nanoparticles with Immobilized and Incorporated Fluorophores and Drugs, Properties and Release Profiles
The synthesis of albumin nanoparticles was performed sequentially using the methods of pH-coacervation, desolvation and cross-linking with glutaraldehyde. The resulting particles have a shape close to spherical. A dependence of the sizes of the resulting particles on the desolvation rate was described. Immobilization of two fluorescent dyes, indocyanine green and sodium fluorescein, as well as the anti-ischemic drug quinacrine, was carried out on the surface of nanoparticles, which made it possible to obtain prolonged release forms. For quinacrine immobilized on the surface of nanoparticles, noticeable release of quinacrine ends by 30 h from the start of the experiment and accounts for 65% of the immobilized active substance. Fluorescent dyes were not released during this period.
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Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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