口服纳米银粒子可被小鼠吸收并迁移至睾丸

IF 4.8 Q2 NANOSCIENCE & NANOTECHNOLOGY
Yuma Saeki, Kazuma Higashisaka, Rina Izutani, Jiwon Seo, Kazuki Miyaji, Yuya Haga, Yasuo Tsutsumi
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引用次数: 0

摘要

鉴于人们现在每天都不可避免地接触纳米粒子,人们担心纳米粒子因其尺寸小而产生意想不到的生物效应。在这里,我们研究了直径为 10 纳米(nAg10)的银纳米粒子(因其抗菌活性而成为最常用的纳米粒子)在雄性生殖道的生物分布情况,以及父亲用 nAg10 处理对胎儿发育的影响。雄性 Slc:ICR 雄性小鼠连续 14 天口服 nAg10。电感耦合等离子体质谱分析法在雄性小鼠的血液和睾丸中检测到了银,但未引起一般毒性反应。此外,当这些经过处理的雄性小鼠与未经过处理的雌性小鼠交配时,胎儿的发育也没有发生明显变化。这意味着虽然口服 nAg10 会分布到雄性生殖道,但在目前的处理条件下不会影响胎儿发育。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Orally Administered Silver Nanoparticles Are Absorbed and Migrate to Testes in Mice

Orally Administered Silver Nanoparticles Are Absorbed and Migrate to Testes in Mice
Given that daily exposure to nanoparticles is now unavoidable, there are concerns that nanoparticles have unexpected biological effects due to their small size. Here, we examined the biodistribution of silver nanoparticles, which are the most frequently used nanoparticles owing to their antibacterial activity, with a diameter of 10 nm (nAg10) to the male genital tract, and the effects of paternal treatment with nAg10 on fetal development. Male Slc:ICR male mice were orally treated with nAg10 for 14 consecutive days. Inductively coupled plasma mass spectrometry analysis detected silver in the blood and testis of male mice, but no general toxicological effects were induced. Moreover, there were no significant changes in fetal development when these treated male mice were mated with nontreated female mice. This implies that although orally ingested nAg10 is distributed to the male genital tract, it does not affect fetal development under the present treatment conditions.
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来源期刊
ACS Nanoscience Au
ACS Nanoscience Au 材料科学、纳米科学-
CiteScore
4.20
自引率
0.00%
发文量
0
期刊介绍: ACS Nanoscience Au is an open access journal that publishes original fundamental and applied research on nanoscience and nanotechnology research at the interfaces of chemistry biology medicine materials science physics and engineering.The journal publishes short letters comprehensive articles reviews and perspectives on all aspects of nanoscience and nanotechnology:synthesis assembly characterization theory modeling and simulation of nanostructures nanomaterials and nanoscale devicesdesign fabrication and applications of organic inorganic polymer hybrid and biological nanostructuresexperimental and theoretical studies of nanoscale chemical physical and biological phenomenamethods and tools for nanoscience and nanotechnologyself- and directed-assemblyzero- one- and two-dimensional materialsnanostructures and nano-engineered devices with advanced performancenanobiotechnologynanomedicine and nanotoxicologyACS Nanoscience Au also publishes original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials engineering physics bioscience and chemistry into important applications of nanomaterials.
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