欧洲血统儿童 C-Reactive 蛋白遗传风险全表型关联研究 (PheWAS):ABCD 研究的结果

Sara A. Norton, Aaron J. Gorelik, Sarah E. Paul, Emma C. Johnson, David AA Baranger, Jayne L Siudzinski, Zhaolong Adrian Li, Erin Bondy, Hailey Modi, Nicole R. Karcher, Tamara Hershey, Alexander S. Hatoum, Arpana Agrawal, Ryan Bogdan
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引用次数: 0

摘要

背景 C-反应蛋白(CRP)是全身炎症的中度遗传标志物,与不良的身心健康结果有关。确定与儿童期 CRP 升高的遗传易感性相关的因素,可以帮助我们了解 CRP 的变异性,从而有针对性地预防和/或延缓相关健康后果的发生。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Phenome-Wide Association Study (PheWAS) of Genetic Risk for C-Reactive Protein in Children of European Ancestry: Results From the ABCD Study
BACKGROUND C-reactive protein (CRP) is a moderately heritable marker of systemic inflammation that is associated with adverse physical and mental health outcomes. Identifying factors associated with genetic liability to elevated CRP in childhood may inform our understanding of variability in CRP that could be targeted to prevent and/or delay the onset of related health outcomes.
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