1 型糖尿病遗传风险评分可对印度人的糖尿病亚型进行分类：HLA 多样性对较低分辨能力的影响

medRxiv - Genetic and Genomic Medicine Pub Date : 2024-08-31 DOI:10.1101/2024.08.31.24312873

Alagu Sankareswaran, Pooja Kunte, Diane P Fraser, Mobeen Shaik, Michael N Weedon, Richard A Oram, Chittaranjan S Yajnik, Giriraj R Chandak

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摘要

目的遗传风险评分（GRS）可对欧洲人的糖尿病类型（1 型糖尿病（T1D）和 2 型糖尿病（T2D））进行分类，但在其他血统中的作用有限。我们探讨了 T1DGRS 的性能以及印度人糖尿病类型分类鉴别能力较差的潜在原因。

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Type 1 Diabetes Genetic Risk Score classifies diabetes subtypes in Indians: Impact of HLA diversity on the lower discriminative ability

Objectives Genetic Risk scores (GRS) classify diabetes types, type 1 (T1D) and type 2 (T2D) in Europeans but the power is limited in other ancestries. We explored the performance of T1DGRS and potential reasons for inferior discrimination ability in diabetes-type classification in Indians.

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medRxiv - Genetic and Genomic Medicine

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