一例伴有两种可能诱因的反应性传染性粘膜糜烂重症病例：冠状病毒和 A 组链球菌

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-09-10 DOI:10.1111/pde.15744

Ivan Rodriguez, Andrew T. Kwong, Minnelly Luu, Scott D. Worswick

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引用次数: 0

摘要

反应性传染性粘膜糜烂（RIME）是一种新定义的疾病，其特征是继发于上呼吸道感染的粘膜水疱，包括肺炎支原体诱发的皮疹和粘膜炎，将疾病谱扩大到包括各种感染病因。我们介绍了一例严重的 RIME 病例，患者是一名 5 岁女性，同时患有冠状病毒 NL63 和 A 组链球菌感染。诊断的复杂性源于与其他严重粘膜糜烂（如史蒂文斯-约翰逊综合征/毒性表皮坏死溶解症/药物性坏死溶解症）重叠的临床特征。本病例强调了进行全面感染检查的必要性，并强调了药物和感染引起的脱屑性皮肤和粘膜疾病的临床诊断范围。

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A severe case of reactive infectious mucocutaneous eruption associated with two possible triggers: Coronavirus and group A streptococcus

Reactive infectious mucocutaneous eruption (RIME) is a newly defined condition characterized by mucocutaneous blistering secondary to upper respiratory infections and encompasses Mycoplasma pneumoniae‐induced rash and mucositis, broadening the disease spectrum to include various infectious etiologies. We present a severe RIME case involving a 5‐year‐old female with concurrent coronavirus NL63 and group A streptococcus infections. Diagnosis complexity stemmed from overlapping clinical features with other severe mucocutaneous eruptions such as Stevens‐Johnson syndrome/toxic epidermal necrolysis/drug‐induced necrolysis. This case underscores the need for comprehensive infectious workup and emphasizes the clinical diagnostic spectrum of drug‐induced and infection‐induced desquamative skin and mucosal disease.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.