趋化因子在肥胖症和运动减肥中的作用

IF 4.8 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomolecules Pub Date : 2024-09-04 DOI:10.3390/biom14091121

Wenbi He, Huan Wang, Gaoyuan Yang, Lin Zhu, Xiaoguang Liu

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引用次数: 0

摘要

肥胖是一种全球性健康危机，与心血管疾病和糖尿病等多种慢性疾病密切相关。本综述深入分析了与肥胖症发病有关的特定趋化因子，包括 C-C motif chemokine ligand 2 (CCL2)、CCL3、CCL5、CCL7、C-X-C motif chemokine ligand 8 (CXCL8)、CXCL9、CXCL10、CXCL14 和 XCL1 (lymphotactin)。这些趋化因子通过促进炎症反应或影响新陈代谢途径和招募免疫细胞，加剧肥胖症状。此外，研究还强调了运动对调节肥胖状态下趋化因子表达的积极作用。值得注意的是，研究探讨了有氧运动以及有氧和阻力训练相结合对降低炎症介质水平、减少胰岛素抵抗和改善代谢健康的潜在作用。这些发现提出了通过运动调节趋化因子水平来干预肥胖症的新策略，为肥胖症的治疗和未来研究提供了新的视角和方向。

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The Role of Chemokines in Obesity and Exercise-Induced Weight Loss

Obesity is a global health crisis that is closely interrelated to many chronic diseases, such as cardiovascular disease and diabetes. This review provides an in-depth analysis of specific chemokines involved in the development of obesity, including C-C motif chemokine ligand 2 (CCL2), CCL3, CCL5, CCL7, C-X-C motif chemokine ligand 8 (CXCL8), CXCL9, CXCL10, CXCL14, and XCL1 (lymphotactin). These chemokines exacerbate the symptoms of obesity by either promoting the inflammatory response or by influencing metabolic pathways and recruiting immune cells. Additionally, the research highlights the positive effect of exercise on modulating chemokine expression in the obese state. Notably, it explores the potential effects of both aerobic exercises and combined aerobic and resistance training in lowering levels of inflammatory mediators, reducing insulin resistance, and improving metabolic health. These findings suggest new strategies for obesity intervention through the modulation of chemokine levels by exercise, providing fresh perspectives and directions for the treatment of obesity and future research.

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来源期刊

Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology

CiteScore

9.40

自引率

3.60%

发文量

1640

审稿时长

18.28 days

期刊介绍： Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.