用于伤口愈合的纳米多孔硅酸钙基辅酶 Q10 的合成与表征

IF 1.8 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

ECS Journal of Solid State Science and Technology Pub Date : 2024-08-27 DOI:10.1149/2162-8777/ad6eb7

Heba Abdel Hafeez Ismail, Doaa Ahmed El-Setouhy, Basant A. Habib, Eman Abdelhakeem, Amany M. El Nahrawy

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引用次数: 0

摘要

本研究探讨了采用溶胶-凝胶工艺合成的生物活性硅酸钙和硅酸钙镁体系中不同辅酶（CoQ10）含量（1-2.5 wt%）的微观结构、光谱和键合排列。研究利用 X 射线衍射 (XRD)、透射电子显微镜和傅立叶变换红外光谱分析样品。研究探讨了傅立叶变换红外键的分配，检查了硅酸盐键环境在 CoQ10 比例影响下的变化。观察到的傅立叶变换红外键的频率偏移和强度变化与生物活性硅酸盐成分有关，是由于在二氧化硅网络中引入了钙镁氧化物和 CoQ10，导致局部对称性降低。XRD 和傅立叶变换红外光谱的结果有助于我们深入了解负载 CoQ10 的硅酸盐基材料的结构作用，从而加深我们对 CoQ10 释放过程的理解。硅酸钙和硅酸钙镁纳米系统中 CoQ10 药物负载的批准是通过傅立叶变换红外光谱带的移动、颗粒分布的变化以及生物活性硅酸钙基纳米颗粒所显示的药物释放活性的评估来实现的。此外，伤口愈合研究显示了硅酸钙镁纳米粒子的生物相容性和伤口愈合反应。

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Synthesis and Characterization of Coenzyme Q10 onto Nanoporous Calcium Silicate-Based Systems for Wound Healing

This study explores the microstructure, spectroscopic, and bonding arrangements within bioactive calcium silicate and calcium magnesium silicate systems loaded with different values (1–2.5 wt%) Coenzyme (CoQ₁₀) ratios, synthesized using sol-gel processes. The investigation utilizes X-ray diffraction (XRD), transmission electron microscopy, and Fourier transform infrared (FTIR) spectroscopy to analyze the samples. The study explores the assignment of FTIR bonds, examining changes in the silicate-based bonds environment under the effect of the CoQ10 ratio. The observed frequency shifts and intensity variations in FTIR bonds, linked with the bioactive silicate composition, are attributed to a reduction in local symmetry resulting from introducing the calcium and magnesium oxides and CoQ₁₀ to the silica network. The XRD and FTIR results contribute valuable insights into the structural role of silicate-based materials loaded with CoQ₁₀, thereby enhancing our understanding of the CoQ₁₀ release process. Approval of the CoQ₁₀ drug loading in both calcium silicate and calcium magnesium silicate nanosystems was recognized by shifts in FTIR bands, changes in particle distribution, and the valuation of drug release activity showed by the bioactive two calcium silicate-based nanoparticles. Additionally, wound healing studies revealed the biocompatibility and wound healing response of calcium magnesium silicate nanoparticles.

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来源期刊

ECS Journal of Solid State Science and Technology MATERIALS SCIENCE, MULTIDISCIPLINARY-PHYSICS, APPLIED

CiteScore

4.50

自引率

13.60%

发文量

455

期刊介绍： The ECS Journal of Solid State Science and Technology (JSS) was launched in 2012, and publishes outstanding research covering fundamental and applied areas of solid state science and technology, including experimental and theoretical aspects of the chemistry and physics of materials and devices. JSS has five topical interest areas: carbon nanostructures and devices dielectric science and materials electronic materials and processing electronic and photonic devices and systems luminescence and display materials, devices and processing.