欧米茄 6/3 比率和 CD68+ 巨噬细胞浸润对接受肺切除术的 NSCLC 患者存活率的潜在影响

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Carlos Déniz, Camilo Moreno, Iván Macía, Francisco Rivas, Anna Ureña, Anna Muñoz, Ines Serratosa, Samantha Aso, Marta García, Cristina Masuet-Aumatell, Ignacio Escobar, Ricard Ramos
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引用次数: 0

摘要

背景:肺癌仍然是全球癌症相关死亡的主要原因,其中非小细胞肺癌(NSCLC)占大多数。检测阶段对生存率有重大影响,早期诊断可提供最佳预后。本研究探讨了欧米伽-6/欧米伽-3比例以及CD8+淋巴细胞和CD68+巨噬细胞的肿瘤浸润对接受肺切除术的NSCLC患者总生存期(OS)和无病生存期(DFS)的预后影响。方法我们对2017年9月至2020年1月期间接受肺切除术的53例早期NSCLC患者进行了回顾性分析。采用气相色谱和光谱法对omega-6/omega-3比率进行了量化。CD8和CD68的肿瘤浸润通过免疫组化进行评估。采用 Kaplan-Meier 和 Cox 回归分析评估生存结果。结果显示ω-6/ω-3比率增加和CD68+巨噬细胞浸润增加与NSCLC患者的OS和DFS恶化趋势有关,但这些结果未达到统计学意义。CD8+ T细胞浸润与生存预后的改善有关,证实了其作为有利预后标志物的作用。与现有数据集的比较分析表明了相似的人口统计学和临床特征,加强了我们研究结果的普遍性。结论ω-6/ω-3比率和CD68+巨噬细胞浸润是潜在影响接受肺切除术的NSCLC患者预后的重要因素。这些发现强调了进一步研究的必要性,以完善这些生物标志物的预后效用,并探索针对炎症和免疫细胞浸润的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Potential Impact of Omega 6/3 Ratio and CD68+ Macrophage Infiltration on Survival in NSCLC Patients Undergoing Pulmonary Resection
Background: Lung cancer remains the leading cause of cancer-related mortality worldwide with non-small cell lung cancer (NSCLC) accounting for the majority of cases. The stage of detection significantly influences survival rates with early-stage diagnosis offering the best prognosis. This study investigates the prognostic impact of the omega-6/omega-3 ratio and tumor infiltration by CD8+ lymphocytes and CD68+ macrophages on overall survival (OS) and disease-free survival (DFS) in NSCLC patients undergoing pulmonary resection. Methods: We conducted a retrospective analysis of 53 patients with early-stage NSCLC who underwent pulmonary resection between September 2017 and January 2020. The omega-6/omega-3 ratio was quantified using gas chromatography and spectrometry. Tumor infiltration by CD8 and CD68 was assessed through immunohistochemistry. Survival outcomes were evaluated using Kaplan-Meier and Cox regression analyses. Results: An increased omega-6/omega-3 ratio and higher CD68+ macrophage infiltration were associated with a trend towards worse OS and DFS in NSCLC patients, though these results did not reach statistical significance. CD8+ T-cell infiltration was associated with improved survival outcomes, confirming its role as a favorable prognostic marker. Comparative analysis with existing datasets revealed similar demographic and clinical characteristics, reinforcing the generalizability of our findings. Conclusions: The omega-6/omega-3 ratio and CD68+ macrophage infiltration serve as important factors potentially influencing prognosis in NSCLC patients undergoing pulmonary resection. These findings highlight the need for further research to refine the prognostic utility of these biomarkers and to explore therapeutic strategies targeting inflammation and immune cell infiltration.
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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