螺化合物的现代电合成

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-08-31 DOI:10.1007/s11172-024-4303-x

M. N. Elinson, Yu. E. Ryzhkova, F. V. Ryzhkov, V. M. Kalashnikova, M. P. Egorov

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引用次数: 0

摘要

由于螺环支架在药物化学中的广泛应用，以及在其基础上设计新的有效药物的需要，螺环支架受到越来越多的关注。电有机合成是制备有机化合物的一种环境友好型方法，因为电流取代了有害和有毒的氧化还原试剂，降低了总体能源成本。本文分析了螺类化合物的现代电合成方法及其发展前景。综述总结了各类电化学和电催化方法的数据。还讨论了这些方法在制备各类螺环化合物中的潜在实际应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Modern electrosynthesis of spiro compounds

Spirocyclic scaffolds have received increasing interest because of their wide use in medicinal chemistry and the need for designing new effective drugs on their basis. Electroorganic synthesis is an environmentally friendly method for the preparation of organic compounds because hazardous and toxic redox reagents are replaced by electric current and the overall energy costs are reduced. Modern methods for the electrosynthesis of spiro compounds and the prospects of their development are analyzed. The review summarizes the data on the types of electrochemical and electrocatalytic methods. The potential practical applications of these methods for the preparation of individual classes of spirocycles are discussed.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.