ABHD5 在癌症生物学中是敌是友？

IF 3.5 3区医学 Q2 ONCOLOGY

Frontiers in Oncology Pub Date : 2024-09-12 DOI:10.3389/fonc.2024.1447509

Jianya Cai, Hongwei Cheng, Shuangta Xu

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引用次数: 0

摘要

含α-β水解酶结构域的5（ABHD5）是脂肪甘油三酯脂肪酶（ATGL）的重要辅助激活剂，ATGL是各种细胞类型中的一种限速酶，可促进三酰甘油（TG）水解成二酰甘油（DG）和脂肪酸（FA）。它是细胞脂质代谢的关键调节因子。脂质代谢的重编程是癌症的特征之一，这表明改变脂质代谢可能成为治疗肿瘤的新策略。研究发现，ABHD5 与恶性肿瘤的发生和发展密切相关。本综述总结了 ABHD5 在各种恶性肿瘤中的作用，并探讨了可能涉及的不同信号通路和代谢途径，从而提供了对 ABHD5 的全面机理认识。

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ABHD5 as a friend or an enemy in cancer biology?

Alpha beta hydrolase domain containing 5 (ABHD5) is an essential coactivator of adipose triglyceride lipase (ATGL), a rate-limiting enzyme in various cell types that promotes the hydrolysis of triacylglycerol (TG) into diacylglycerol (DG) and fatty acid (FA). It acts as a critical regulatory factor in cellular lipid metabolism. The reprogramming of lipid metabolism is one of the hallmarks of cancer, suggesting that altering lipid metabolism could become a new strategy for tumor treatment. Research has revealed a close association between ABHD5 and the development and progression of malignancies. This review summarizes the role of ABHD5 in various malignant tumors and explores the different signaling pathways and metabolic routes that may be involved, providing a comprehensive mechanistic understanding of ABHD5.

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来源期刊

Frontiers in Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

6.20

自引率

10.60%

发文量

6641

审稿时长

14 weeks

期刊介绍： Cancer Imaging and Diagnosis is dedicated to the publication of results from clinical and research studies applied to cancer diagnosis and treatment. The section aims to publish studies from the entire field of cancer imaging: results from routine use of clinical imaging in both radiology and nuclear medicine, results from clinical trials, experimental molecular imaging in humans and small animals, research on new contrast agents in CT, MRI, ultrasound, publication of new technical applications and processing algorithms to improve the standardization of quantitative imaging and image guided interventions for the diagnosis and treatment of cancer.