吲哚的催化硫代甲基化反应

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2024-08-31 DOI:10.1007/s11172-024-4315-6

V. R. Akhmetova, D. V. Leont’ev, N. S. Akhmadiev, E. A. Paramonov

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引用次数: 0

摘要

研究了在酸和碱、氧化磷以及 I2/NaOH 氧化体系存在下，甲醛-硫醇试剂体系对 1H-indole 和色氨酸直接硫代甲基化反应的催化作用。根据中间化合物的质谱研究结果，提出了多组分硫代甲基化反应的催化机理。

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Catalytic thiomethylation of indoles

The catalysis of direct thiomethylation of 1H-indole and tryptophan under the action of the formaldehyde—mercaptan reagent system in the presence of acids and bases, phosphorus oxide and the oxidative system I₂/NaOH was studied. A mechanism for the catalysis of the multicomponent thiomethylation reaction was proposed based on the results of mass spectrometric study of intermediate compounds.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.