人体血液中的随机激光分析

Biosensors Pub Date : 2024-09-13 DOI:10.3390/bios14090441
Sergio de Armas-Rillo, Beatriz Abdul-Jalbar, Josmar Salas-Hernández, Jose María Raya-Sánchez, Tomás González-Hernández, Fernando Lahoz
{"title":"人体血液中的随机激光分析","authors":"Sergio de Armas-Rillo, Beatriz Abdul-Jalbar, Josmar Salas-Hernández, Jose María Raya-Sánchez, Tomás González-Hernández, Fernando Lahoz","doi":"10.3390/bios14090441","DOIUrl":null,"url":null,"abstract":"Random lasing (RL) is an optical phenomenon that arises from the combination of light amplification with optical feedback through multiple scattering events. In this paper, we present our investigations of RL generation from human blood samples. We tested mixtures of rhodamine B dye solutions with different blood components, including platelets, lymphocytes, erythrocytes, and whole blood. Intense coherent RL was obtained in all cases at relatively low pump thresholds, except for erythrocytes. We also studied the potential of RL signal analysis for biosensing applications using blood samples from healthy individuals and patients suffering from Chronic Lymphocytic Leukemia (CLL). CLL is a blood disease characterized by a high count of lymphocytes with significant morphological changes. A statistical analysis of the RL spectra based on principal component and linear discriminant analyses was conducted for classification purposes. RL-based sample discrimination was conducted for whole blood, platelet, and lymphocyte samples, being especially successful (86.7%) for the latter. Our results highlight the potential of RL analysis as a sensing tool in blood.","PeriodicalId":100185,"journal":{"name":"Biosensors","volume":"14 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Analysis of Random Lasing in Human Blood\",\"authors\":\"Sergio de Armas-Rillo, Beatriz Abdul-Jalbar, Josmar Salas-Hernández, Jose María Raya-Sánchez, Tomás González-Hernández, Fernando Lahoz\",\"doi\":\"10.3390/bios14090441\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Random lasing (RL) is an optical phenomenon that arises from the combination of light amplification with optical feedback through multiple scattering events. In this paper, we present our investigations of RL generation from human blood samples. We tested mixtures of rhodamine B dye solutions with different blood components, including platelets, lymphocytes, erythrocytes, and whole blood. Intense coherent RL was obtained in all cases at relatively low pump thresholds, except for erythrocytes. We also studied the potential of RL signal analysis for biosensing applications using blood samples from healthy individuals and patients suffering from Chronic Lymphocytic Leukemia (CLL). CLL is a blood disease characterized by a high count of lymphocytes with significant morphological changes. A statistical analysis of the RL spectra based on principal component and linear discriminant analyses was conducted for classification purposes. RL-based sample discrimination was conducted for whole blood, platelet, and lymphocyte samples, being especially successful (86.7%) for the latter. Our results highlight the potential of RL analysis as a sensing tool in blood.\",\"PeriodicalId\":100185,\"journal\":{\"name\":\"Biosensors\",\"volume\":\"14 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biosensors\",\"FirstCategoryId\":\"0\",\"ListUrlMain\":\"https://doi.org/10.3390/bios14090441\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biosensors","FirstCategoryId":"0","ListUrlMain":"https://doi.org/10.3390/bios14090441","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

随机激光(RL)是一种光学现象,它是通过多次散射事件将光放大与光反馈相结合而产生的。本文介绍了我们对人体血液样本产生随机激光的研究。我们测试了罗丹明 B 染料溶液与不同血液成分(包括血小板、淋巴细胞、红细胞和全血)的混合物。除红细胞外,所有情况下都能在相对较低的泵阈值下获得强烈的相干 RL。我们还利用健康人和慢性淋巴细胞白血病(CLL)患者的血液样本,研究了 RL 信号分析在生物传感应用中的潜力。慢性淋巴细胞白血病是一种血液疾病,其特点是淋巴细胞数量多且形态变化明显。基于主成分分析和线性判别分析对 RL 光谱进行了统计分析,以便进行分类。对全血、血小板和淋巴细胞样本进行了基于 RL 的样本判别,后者的判别尤其成功(86.7%)。我们的结果凸显了 RL 分析作为血液传感工具的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Analysis of Random Lasing in Human Blood
Random lasing (RL) is an optical phenomenon that arises from the combination of light amplification with optical feedback through multiple scattering events. In this paper, we present our investigations of RL generation from human blood samples. We tested mixtures of rhodamine B dye solutions with different blood components, including platelets, lymphocytes, erythrocytes, and whole blood. Intense coherent RL was obtained in all cases at relatively low pump thresholds, except for erythrocytes. We also studied the potential of RL signal analysis for biosensing applications using blood samples from healthy individuals and patients suffering from Chronic Lymphocytic Leukemia (CLL). CLL is a blood disease characterized by a high count of lymphocytes with significant morphological changes. A statistical analysis of the RL spectra based on principal component and linear discriminant analyses was conducted for classification purposes. RL-based sample discrimination was conducted for whole blood, platelet, and lymphocyte samples, being especially successful (86.7%) for the latter. Our results highlight the potential of RL analysis as a sensing tool in blood.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信